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From Viral Infection to Skin Affliction: Unveiling Mechanisms of Cutaneous Manifestations in COVID-19 and Post-COVID Conditions.
J Invest Dermatol
February 2025
Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Dermatology, Women's College Hospital, Toronto, Canada. Electronic address:
COVID-19 skin manifestations are multifaceted, ranging from urticaria, morbilliform or papulovesicular rash, livedoid purpuric lesions, and to pseudochilblains (also called COVID toes). Recent insights into the mechanism of these manifestations have highlighted that morbilliform, papulovesicular, and livedoid/purpuric rashes are related to virus-induced endothelial cell damage and linked to moderate-to-severe disease, whereas pseudochilblains are related to an exaggerated IFN-1 production by plasmacytoid dendritic cells in protected individuals. In this paper, we will review the clinical and physiopathological features of cutaneous COVID-19 manifestations in relation to the direct viral cytopathic effects and dysregulated IFN-1 responses.
View Article and Find Full Text PDFPapulovesicular Riddle in an Atopic Individual.
Cureus
April 2024
Internal Medicine, Saint Peter's University Hospital, New Brunswick, USA.
Article Synopsis
- Atopic dermatitis (AD) leads to skin irritation and can increase the risk of infections, especially in those affected by the condition.
- Eczema herpeticum (EH) is a serious herpes simplex infection that appears as vesicles and erosions in areas already affected by AD, and misdiagnosing it can have severe consequences.
- Prompt identification and treatment with acyclovir are essential to prevent serious complications, as illustrated by a case involving a 19-year-old male with AD presenting a similar rash.
Papulo-vesicular eruption and profound unilateral hearing loss in a 20-year-old man.
J Dtsch Dermatol Ges
May 2024
Department of Dermatology and Venereology, Faculty of Medicine, University of Cologne, and University Hospital of Cologne, Cologne, Germany.
A Case of Acral Papulovesicular Rash Associated With COVID-19.
Cureus
March 2024
Dermatology, Near East University, Faculty of Medicine, Nicosia, CYP.
COVID-19 is a global pandemic that started in 2020. During the pandemic, patients have presented with various cutaneous manifestations of COVID-19 infections. Currently, COVID-19 infections are still present worldwide, although to a lesser extent.
View Article and Find Full Text PDFAcantholytic Dyskeratosis Consistent With Grover's Disease After Letrozole Therapy.
Cureus
February 2024
Dermatology, Family Dermatology of North Florida, Tallahassee, USA.
Article Synopsis
- A case study details a 66-year-old woman with stage IV breast cancer who developed Grover's disease (GD) while being treated with letrozole, a common breast cancer medication.
- GD is characterized by itchy skin lesions typically on the chest and trunk, and in this case, it was initially misdiagnosed as contact dermatitis.
- After stopping letrozole and using topical steroids, the patient's condition improved, highlighting the need for awareness of drug-induced skin reactions in cancer treatments and the limited existing research on GD related to letrozole.
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