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Age Is Just a Number: Ontogenetic Conservation in Activation of Blood Clotting Factors VII, X, and XII by Caucasus Blunt-Nosed Viper () Venoms.
Toxins (Basel)
December 2024
Adaptive Biotoxicology Lab, School of the Environment, University of Queensland, St Lucia, QLD 4072, Australia.
This study examined the pathophysiological effects of venoms from neonate and adult specimens of the viperid snake , focusing on their ability to activate various blood clotting factors in human plasma. All venoms exhibited strong procoagulant properties. In concentration-response tests, the clotting potency of the neonate venoms fell within the range of their parents' maximum clotting velocities and areas under the curve.
View Article and Find Full Text PDFExploring developmental changes in femoral midneck cross-sectional properties.
Anat Rec (Hoboken)
December 2024
Laboratorio de Evolución Humana, Universidad de Burgos, Edificio I+D+i/CIBA, Burgos, Spain.
This research delves deeper into previous works on femoral cross-sectional properties during ontogeny by focusing for the first time on the human femoral midneck. The ontogenetic pattern of cross-sectional properties at femoral midneck is established and compared with those at three different femoral locations: the proximal femur, the midshaft, and the distal femur. The study sample includes 99 femora (70 non-adults and 29 adults) belonging to archaeological specimens.
View Article and Find Full Text PDFAgency as an Inherent Property of Living Organisms.
Biol Theory
August 2024
Institute of Evolutionary Biology and Morphology Centre for Biomedical Education and Research, Faculty of Health, School of Medicine, Witten/Herdecke University, Witten, Germany.
A central characteristic of living organisms is their agency, that is, their intrinsic activity, both in terms of their basic life processes and their behavior in the environment. This aspect is currently a subject of debate and this article provides an overview of some of the relevant publications on this topic. We develop the argument that agency is immanent in living organisms.
View Article and Find Full Text PDFThe influence of biomimetic conditions on neurogenic and neuroprotective properties of dedifferentiated fat cells (DFATs).
Stem Cells
November 2024
Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
In the era of a constantly growing number of reports on the therapeutic properties of dedifferentiated, ontogenetically rejuvenated cells and their use in the treatment of neurological diseases, the optimization of their derivation and long-term culture methods seem to be crucial. One of the solutions is seen in the use of dedifferentiated fat cells (DFATs) which are characterized by a greater homogeneity. Moreover, these cells seem to possess a higher expression of transcriptional factors necessary to maintain pluripotency (STRFs) as well as a greater ability to differentiate in vitro into three embryonic germ layers, and a high proliferative potential in comparison to adipose stem/stromal cells (ASCs).
View Article and Find Full Text PDFInducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis.
J Clin Invest
October 2024
Division of Thoracic Surgery/Canning Thoracic Institute, Feinberg School of Medicine, Northwestern University/Northwestern Medicine, Chicago, Illinois, USA.
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for the promotion of metastasis and resistance to immunosurveillance. In the circulation, some CCR2-expressing classical monocytes lose CCR2 and differentiate into intravascular nonclassical monocytes that have anticancer properties but are unable to access extravascular tumor sites.
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