Objective: We describe the diagnose and treatment of patient with anaplastic astrocytoma in the third trimestr of pregnancy.
Design: Case report.
Setting: Department of Gynecology and Obstetrics, Regional Hospital Liberec.
Conclusion: Malignant brain tumors are fortunately a rare disease. There is no difference in incidence between pregnant and non-pregnant women, but faster development of symptoms and progression of disease is suspected. There is a problem of small number of patients in these studies. In our opinion most important is early and effective multidisciplinary management according to condition of patient and age of pregnancy.
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Sci Adv
January 2025
School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
The prevalent tumor-supporting glioblastoma-associated macrophages (GAMs) promote glioblastoma multiforme (GBM) progression and resistance to multiple therapies. Repolarizing GAMs from tumor-supporting to tumor-inhibiting phenotype may troubleshoot. However, sufficient accumulation of drugs at the GBM site is restricted by blood-brain barrier (BBB).
View Article and Find Full Text PDFMed Oncol
January 2025
Department of Medical Pharmacology, Medical Faculty, Atatürk University, Erzurum, Turkey.
Limited advancements in managing malignant brain tumors have resulted in poor prognoses for glioblastoma (GBM) patients. Standard treatment involves surgery, radiotherapy, and chemotherapy, which lack specificity and damage healthy brain tissue. Boron-containing compounds, such as boric acid (BA), exhibit diverse biological effects, including anticancer properties.
View Article and Find Full Text PDFActa Neurochir (Wien)
January 2025
Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), Neurosurgical Unit, University of Palermo, Palermo, Italy.
Objective: Communicating hydrocephalus (CH) is an uncommon complication that can affect patients with glioblastoma (GBM). Due to its clinical and radiological findings, it presents as a chronic hydrocephalus. The mechanisms underlying its occurrence and impact on the prognosis of the disease are poorly known, but some studies have suggested that shunting can have a positive impact on the quality of life of these patients.
View Article and Find Full Text PDFCommun Biol
January 2025
Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 430000, China.
Hypoxia is a common feature of glioblastoma (GBM). Circular RNAs (circRNAs) are identified as regulators in cancers. However, the role of circRNAs in GBM remains elusive.
View Article and Find Full Text PDFAn assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of tumor morphology and MRI characteristics. 74 gross tumor core and T2-FLAIR hyper-intensity BraTS-Toolkit and DeepBraTumIA automatic segmentations, and 42 gross tumor core neurosurgeon manual segmentations were accordingly evaluated. Brats-Toolkit and DeepBraTumIA generally provide accurate segmentations, particularly for the most common round-shaped or well-demarked tumors, where: (1) gross tumor segmentation correctly includes necrosis and contrast enhanced tumor in 100% and 97.
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