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http://dx.doi.org/10.3389/fnins.2018.00310 | DOI Listing |
J Med Chem
January 2025
Experimental Drug Development Centre, Chromos, Agency for Science, Technology and Research, 10 Biopolis Road, #05-01, Singapore 138670.
The discovery of molecular glues has made significant strides, unlocking new avenues for targeted protein degradation as a therapeutic strategy, thereby expanding the scope of drug discovery into territories previously considered undruggable. Pioneering molecules like thalidomide and its derivatives have paved the way for the development of small molecules that can induce specific protein degradation by hijacking the cellular ubiquitin-proteasome system. Recent advancements have focused on expanding the range of E3 ligases and target proteins that can be modulated by molecular glues.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
Department Biochemistry & Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, Spain.
Nanotechnology has substantial potential for advancements in the fields of biology and medicine [...
View Article and Find Full Text PDFCurr Issues Mol Biol
December 2024
Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea.
Despite significant advancements in plant breeding research, the challenges posed by a growing global population, the impact of abiotic and biotic stresses, and the uncertainties of climate change necessitate continued focus and innovation in plant breeding and genetic studies [...
View Article and Find Full Text PDFBiomimetics (Basel)
January 2025
Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Research Campus Golm, Am Mühlenberg 1, 14476 Potsdam, Germany.
Biomimetics research on living systems attempts to transfer their properties and functions to engineering applications [...
View Article and Find Full Text PDFBioengineering (Basel)
January 2025
Department of Information Engineering, Università Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy.
This Special Issue (SI), "Data Processing and Machine Learning for Assistive and Rehabilitation Technologies", aimed to collect cutting-edge research papers that frame how data-driven approaches and machine learning techniques are advancing the field of assistive and rehabilitation technologies [...
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!