The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) , was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC of 0.5/4 μg/ml and sustained 3-log kill against MDR , , and spp.
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| http://dx.doi.org/10.1128/AAC.00236-18 | DOI Listing |
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