Piperaquine is an important partner drug used in artemisinin-based combination therapies (ACTs). An increase in the and gene copy numbers has been associated with decreased susceptibility of to piperaquine in Cambodia. Here, we developed a photo-induced electron transfer real-time PCR (PET-PCR) assay to quantify the copy number of the gene () that can be used in countries where is endemic to enhance molecular surveillance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105858 | PMC |
| http://dx.doi.org/10.1128/AAC.00317-18 | DOI Listing |
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