We report a case of Cogan's syndrome presenting as fever of unknown origin in a 31-year-old woman who was admitted to the hospital with a 7-week history of fever, night sweats and other constitutional symptoms. The diagnosis remained elusive despite numerous investigations, and the patient subsequently developed rash, episcleritis, dizziness and sensorineural hearing loss. While initially thought to be a postinflammatory response to a previous infection, confirmation of the rash as a vasculitis together with the audiovestibular and ocular involvement led to a clinical diagnosis of Cogan's syndrome. This was further corroborated by resolution of her symptoms once immunosuppressive therapy was instituted. Early recognition of Cogan's syndrome is crucial to reducing the risk of serious complications through the timely initiation of treatment.
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http://dx.doi.org/10.1136/bcr-2017-224031 | DOI Listing |
J Clin Neurol
January 2025
Dizziness Center, Clinical Neuroscience Center, Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
BMJ Case Rep
December 2024
Department of Otorhinolaryngology and Head and Neck Surgery, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany
We present a case series consisting of three female patients in their 30s with presumed autoimmune uveitis resembling Cogan's syndrome following caesarean sections (C-sections) with severe intraoperative bleeding and the use of chitosan-tamponade, exhibiting a combination of varying ocular and auditory symptoms postoperatively. Our patients displayed a range of inflammatory ocular changes, including stromal keratitis, panuveitis, retinal infiltrates, haemorrhages, optic disc swelling, and intraretinal and subretinal fluid, along with otalgia and hearing loss, consistent with typical and atypical Cogan's syndrome. Treatment involved systemic corticosteroids, resulting in variable outcomes.
View Article and Find Full Text PDFArch Soc Esp Oftalmol (Engl Ed)
December 2024
Departamento de Oftalmología, Hospital de la Familia, Nuevo Progreso, San Marcos, Guatemala. Electronic address:
Case Report: Case report of a 51 year old patient diagnosed with atypical Cogan's syndrome. The patient exhibited interstitial keratitis, anterior uveitis, and long-standing profound deafness. The treatment was based on topical and systemic steroids, resulting in a satisfactory evolution and currently in clinical remission.
View Article and Find Full Text PDFJ Med Case Rep
November 2024
Vertigo Center, Cheikh Khalifa International University HospitalMohammed VI University of Health Sciences, Casablanca, Morocco.
Background: Cogan syndrome is a rare autoimmune systemic vasculitis presenting with interstitial keratitis and audiovestibular symptoms. The atypical form, characterized by more extensive ocular lesions with audiovestibular symptoms appearing with a longer delay and more frequent systemic features, is usually underdiagnosed, delaying treatment.
Case Presentation: We report the case of a 30-year-old Mediterranean female who presented recurrent left red and painful eye.
Health Educ Behav
October 2024
American Academy of Family Physicians, Leawood, KS, USA.
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