An actinomycete strain TRM20105 with antifungal activity was identified as subsp. DSM43111 (98.34% similarity) by 16S rDNA phylogenetic analysis and morphology observation. The fermentation broth of TRM20105 cultured with oat-soybean medium was subjected to discover bioactive compounds. Guided by antifungal bioassay against , a new diketopiperazine compound was purified via various column chromatographies together with pHPLC. The purified active compound was identified as 1-demethylnocazine A, (3Z,6Z)-5-methoxy-3,6-bis(4-methoxybenzylidene) -1,6-dihydropyrazin-2(3)-one by the analyses of 1D & 2D NMR data.
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| http://dx.doi.org/10.1080/14786419.2018.1475389 | DOI Listing |
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A new diketopiperazine isolated from a strain TRM20105 guided by bioassay against .
Nat Prod Res
December 2019
Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Science, Tarim University, Alar , China.
An actinomycete strain TRM20105 with antifungal activity was identified as subsp. DSM43111 (98.34% similarity) by 16S rDNA phylogenetic analysis and morphology observation.
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