The purpose of this study was to improve risk stratification of smoldering multiple myeloma patients, introducing new 3D-volumetry based imaging biomarkers derived from whole-body MRI. Two-hundred twenty whole-body MRIs from 63 patients with smoldering multiple myeloma were retrospectively analyzed and all focal lesions >5mm were manually segmented for volume quantification. The imaging biomarkers total tumor volume, speed of growth (development of the total tumor volume over time), number of focal lesions, development of the number of focal lesions over time and the recent imaging biomarker '>1 focal lesion' of the International Myeloma Working Group were compared, taking 2-year progression rate, sensitivity and false positive rate into account. Speed of growth, using a cutoff of 114mm/month, was able to isolate a high-risk group with a 2-year progression rate of 82.5%. Additionally, it showed by far the highest sensitivity in this study and in comparison to other biomarkers in the literature, detecting 63.2% of patients who progress within 2 years. Furthermore, its false positive rate (8.7%) was much lower compared to the recent imaging biomarker '>1 focal lesion' of the International Myeloma Working Group. Therefore, speed of growth is the preferable imaging biomarker for risk stratification of smoldering multiple myeloma patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982766 | PMC |
| http://dx.doi.org/10.18632/oncotarget.25402 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SP-YOLO: A Real-Time and Efficient Multi-Scale Model for Pest Detection in Sugar Beet Fields.
Insects
January 2025
College of Life Science and Technology, Xinjiang University, Urumqi 830017, China.
Beet crops are highly vulnerable to pest infestations throughout their growth cycle, which significantly affects crop development and yield. Timely and accurate pest identification is crucial for implementing effective control measures. Current pest detection tasks face two primary challenges: first, pests frequently blend into their environment due to similar colors, making it difficult to capture distinguishing features in the field; second, pest images exhibit scale variations under different viewing angles, lighting conditions, and distances, which complicates the detection process.
View Article and Find Full Text PDFFormation of a Novel Antagonistic Bacterial Combination to Enhance Biocontrol for Cucumber Wilt.
Microorganisms
January 2025
Institute of Vegetable, Henan Academy of Agricultural Sciences, Graduate T&R Base of Zhengzhou University, Zhengzhou 450002, China.
strain PJH16, isolated and tested by our team, suppresses cucumber wilt as an efficient biocontrol agent. For further investigation, the strain has been combined with two other ( VJH504 and JNF2) to enhance biocontrol ability, which formed high-efficiency microbial agents in the current study. The methodological target taken is based on achieving the optimal growth conditions of the combined microbial agents; hence, the medium composition and culture conditions were optimized through a single-factor test, orthogonal test and response surface methodology.
View Article and Find Full Text PDFDNA Damage Response Mutants Challenged with Genotoxic Agents-A Different Experimental Approach to Investigate the and Genes.
Genes (Basel)
January 2025
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.
DNA damage response (DDR) is a highly conserved and complex signal transduction network required for preserving genome integrity. DNA repair pathways downstream of DDR include the tyrosyl-DNA phosphodiesterase1 (TDP1) enzyme that hydrolyses the phosphodiester bond between the tyrosine residue of topoisomerase I (TopI) and 3'-phosphate end of DNA. A small TDP1 subfamily, composed of TDP1α and TDP1β, is present in plants.
View Article and Find Full Text PDFMetabolomic Insights into the Allelopathic Effects of (Mill.) Swingle Volatile Organic Compounds on the Germination Process of (L.).
Metabolites
January 2025
Department of Agricultural and Environmental Sciences-Production, Landscape, Agroenergy, University of Milan, 20133 Milan, Italy.
This study explores the allelopathic effects of volatile organic compounds (VOCs) emitted by the invasive species (Mill.) Swingle on the seed germination of . is known for releasing allelopathic VOCs that suppress the growth of neighbouring plants, contributing to its invasive potential.
View Article and Find Full Text PDFGrowth Propagation of Liquid Spawn on Non-Woven Hemp Mats to Inform Digital Biofabrication of Mycelium-Based Composites.
Biomimetics (Basel)
January 2025
Research Group Architectural Engineering, Department of Architecture, KU Leuven, 3001 Leuven, Belgium.
Mycelium-based composites (MBCs) are highly valued for their ability to transform low-value organic materials into sustainable building materials, offering significant potential for decarbonizing the construction sector. The properties of MBCs are influenced by factors such as the mycelium species, substrate materials, fabrication growth parameters, and post-processing. Traditional fabrication methods involve combining grain spawn with loose substrates in a mold to achieve specific single functional properties, such as strength, acoustic absorption, or thermal insulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!