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Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production.
Front Immunol
January 2025
Faculty of Medicine, University of Castilla-La Mancha, Albacete, Spain.
Introduction: Despite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since the impact of COVID-19 vaccines on the endothelium remains uncertain, our objective was to assess endothelial activation status before and 90 days after the third dose of the BNT162b2 mRNA COVID-19 vaccine.
Methods: A prospective longitudinal study was conducted at University General Hospital of Albacete, involving 38 healthy health-care workers.
Vitamin D and COVID-19: comparative analysis with other respiratory infections and impact of comorbidities.
Germs
September 2024
Pharm, PhD, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, No. 6 Traian Vuia street, Bucharest, 020956, Romania.
Introduction: The COVID-19 pandemic has promoted an intensive investigation into the pathophysiological mechanisms of SARS-CoV-2 infection, risk factors, and its impact on disease severity. Vitamin D has generated significant attention for its potential role in viral prevention and immune defense due to its pleiotropic functions, including immunomodulation and antimicrobial effects. This study aimed to assess serum 25(OH)D3 levels in patients with COVID-19 compared to those with other viral respiratory infections and to evaluate associations of vitamin D levels with symptomatology, clinical characteristics, presence of comorbidities and laboratory investigation.
View Article and Find Full Text PDFAssociation between serum endocan levels and organ failure in hospitalized patients with cirrhosis.
PLoS One
December 2024
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Background & Aims: Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endothelial dysfunction plays a key role in the development of organ failure.
View Article and Find Full Text PDFRelation of Endocan Serum Levels with Patient Characteristics and Morphological Features of Uterine Fibroids: A Case-Control Study.
Gynecol Obstet Invest
November 2024
Gynecology and Obstetrics Departments, Ankara City Hospital, Ankara, Turkey.
Objectives: This study aimed to compare the serum endocan levels of patients with uterine fibroids and the healthy control group.
Design: A case-control study was designed. Participants/Materials: The study group includes women diagnosed with uterine fibroids, and the control group includes healthy women.
Serum endocan (ESM-1) as diagnostic and prognostic biomarker in Multisystem inflammatory syndrome in children (MIS-C).
Cytokine
December 2024
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy; CEINGE-Biotecnologie Avanzate S.c.a.r.l., Naples, Italy.
Article Synopsis
- Endothelial-cell-specific molecule-1 (ESM-1), also known as endocan, is identified as a significant biomarker for inflammation and cardiovascular risk in COVID-19 patients, particularly in the context of Multisystem Inflammatory Syndrome in children (MIS-C).
- In a study comparing ESM-1 levels between MIS-C patients and healthy controls, MIS-C patients showed significantly higher levels of ESM-1, suggesting its potential diagnostic value.
- The research indicates that ESM-1 not only correlates with other inflammatory markers but is also associated with cardiac complications, highlighting its role in assessing cardiovascular risks in MIS-C patients and aiding in treatment strategies.
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