AI Article Synopsis
- Survivin is an important target in cancer treatment because it helps regulate cell division and apoptosis (programmed cell death).
- There are only a few inhibitors developed that target Survivin, and most work by altering other biomolecules rather than binding directly to the Survivin protein.
- The review outlines the structure of the Survivin protein, how its inhibitors work, and recent research, highlighting the potential for developing more selective Survivin inhibitors in the future.
Article Abstract
Survivin, a member of the inhibitor of apoptosis proteins family, is considered to be an important target of anticancer treatment for its key role in the control of cell division and cell apoptosis. Currently, only a few Survivin inhibitors have been developed, and most of them reduce Survivin level by interacting with other biomolecules instead of directly interacting with Survivin protein. This review summarizes the structure of Survivin protein, the mechanism of action and research progress of Survivin inhibitors, which may has a great significance in the study of selective Survivin inhibitors in the future.
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