Hormesis, a biphasic dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition, is a common feature of medicines but neglected sometime. Understanding of hormesis is essential for drug discovery and clinical application. Assessing hormetic range needs a proper experiment design including the number of doses and dose spacing, especially in the low dose zone. This article provides the shapes of hormetic dose-response curves, underlying mechanisms and the significance of hormesis for drugs of infectious diseases to facilitate drugs development and clinical applications.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
drugs infectious
8
[hormesis drugs
4
infectious diseases]
4
diseases] hormesis
4
hormesis biphasic
4
biphasic dose-response
4
dose-response phenomenon
4
phenomenon characterized
4
characterized low-dose
4
low-dose stimulation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!