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Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles. | LitMetric

Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles.

Org Lett

Willard Henry Dow Laboratory, Department of Chemistry , University of Michigan , 930 North University Avenue, Ann Arbor , Michigan 48109 , United States.

Published: June 2018

A net redox-neutral method for the decarboxylative alkylation of heteroarenes using photoredox catalysis is reported. Additionally, this method features the use of simple, commercially available carboxylic acid derivatives as alkylating agents, enabling the facile alkylation of a variety of biologically relevant heterocyclic scaffolds under mild conditions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014829PMC
http://dx.doi.org/10.1021/acs.orglett.8b01250DOI Listing

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