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Improving large language model applications in biomedicine with retrieval-augmented generation: a systematic review, meta-analysis, and clinical development guidelines.
J Am Med Inform Assoc
January 2025
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
Objective: The objectives of this study are to synthesize findings from recent research of retrieval-augmented generation (RAG) and large language models (LLMs) in biomedicine and provide clinical development guidelines to improve effectiveness.
Materials And Methods: We conducted a systematic literature review and a meta-analysis. The report was created in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 analysis.
Success Rates of Assisted Reproduction for Men With Cystic Fibrosis.
Pediatr Pulmonol
January 2025
Department of Respiratory Medicine, Manchester Adult Cystic Fibrosis Centre, North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Background: The vast majority of men with CF (mwCF) are infertile. Improvements in assisted reproductive technology (ART) have made it possible for these patients to become biological fathers.
Methods: Data were examined for all male CF patients attending a large adult CF center over a 23-year period.
Tranexamic acid for preventing postpartum haemorrhage after vaginal birth.
Cochrane Database Syst Rev
January 2025
Department of Obstetrics and Gynaecology, University of Botswana, Gaborone, Botswana.
Rationale: Postpartum haemorrhage (PPH) is common and potentially life-threatening. The antifibrinolytic drug tranexamic acid (TXA) is thought to be effective for treating PPH. There is growing interest in whether TXA is effective for preventing PPH after vaginal birth.
View Article and Find Full Text PDFPercutaneous thrombectomy of fat embolism in-transit.
J Vasc Surg Cases Innov Tech
April 2025
Hoag Hospital Irvine, Irvine, CA.
We report the case of a previously independent 82-year-old female who experienced acute hemodynamic and respiratory deterioration requiring inotropic support due to a fat embolism during revision hip arthroplasty. Computed tomography pulmonary angiography demonstrated fat embolism, and transesophageal echocardiogram showed evidence of right ventricle strain and fat embolism in-transit in the right heart, as well as a moderate patent foramen ovale. Under transesophageal echocardiogram and intravascular ultrasound guidance, the Inari FlowTriever thrombectomy device was used successfully to retrieve the fat embolism with immediate hemodynamic improvement, no complications, and uneventful recovery.
View Article and Find Full Text PDFIntegrating and retrieving learning analytics data from heterogeneous platforms using ontology alignment: Graph-based approach.
MethodsX
June 2025
Fakulti Teknologi Maklumat dan Komunikasi, Universiti Teknikal Malaysia Melaka, 76100 Melaka, Malaysia.
This study explores the possibility of integrating and retrieving heterogenous data across platforms by using ontology graph databases to enhance educational insights and enabling advanced data-driven decision-making. Motivated by some of the well-known universities and other Higher Education Institutions ontology, this study improvises the existing entities and introduces new entities in order to tackle a new topic identified from the preliminary interview conducted in the study to cover the study objective. The paper also proposes an innovative ontology, referred to as Student Performance and Course, to enhance resource management and evaluation mechanisms on course, students, and MOOC performance by the faculty.
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