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Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury. | LitMetric

AI Article Synopsis

  • Oxidative stress occurs when there's an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to cellular damage and reduced physiological functions.
  • The study evaluated age-related changes in ROS levels and oxidative markers in F344 rats at different ages (2, 8, and 15 months), focusing particularly on the liver.
  • Findings revealed that by middle age, there is an increase in circulating ROS and protein carbonyls, with older rats showing higher levels of oxidative DNA damage and reduced capacity to repair it, indicating that plasma protein carbonyls could serve as markers for oxidative injury in organs.

Article Abstract

Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense mechanisms, plays a major role in inducing oxidative damage and cellular impairment, resulting in a general decline of the physiological functions. The aim of this work was to evaluate age-related changes in circulating ROS levels and plasma protein carbonyls, in very young (2 months aged), young (8 months aged) and in middle age (15 months aged) F344 rats. In addition, the DNA oxidative marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the expression of the DNA repair enzymes and genes were also measured in the liver of these animals. We also determined whether systemic oxidative stress reflects oxidative injury at organ level. Our results demonstrate that the increase in circulating ROS and protein carbonyl content occurs as early as middle age. Moreover, increased 8-OHdG in the liver of 15-month-old rats was at least in part associated with a reduced DNA damage repairing capacity as suggested by the down-regulation of gene expression. In addition, we demonstrated for the first time, that plasma carbonyls and liver 8-OHdG are well correlated, suggesting that plasma protein carbonyls may be used as a surrogate marker of oxidative injury in target organs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977162PMC
http://dx.doi.org/10.1016/j.toxrep.2017.12.017DOI Listing

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