() is associated with human gastroenteritis; however, was isolated and confirmed by phenotypic and genotypic identification from a non-diarrheal child stool sample in Cambodia. Antimicrobial susceptibility testing demonstrated that this isolate had a high minimal inhibitory concentration against macrolides and quinolones, which are first-line antibiotic treatment choices for infections. Consequently, macrolides and quinolones were likewise expected to be ineffective against -like organisms such as . This isolate warranted further genetic characterization to better understand associated antibiotic resistance mechanisms. Resistant pathogens from asymptomatic diarrheal cases are likely underestimated, and as such colonized individuals may spread resistant organisms to local community members and the environment.
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http://dx.doi.org/10.1186/s13099-018-0246-9 | DOI Listing |
Nat Commun
September 2024
Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
Diarrhea claims >500,000 lives annually among children under five years of age in low- and middle-income countries. Mortality due to acute diarrhea (<7 days' duration) is decreasing, but prolonged (7-13 days) and persistent (≥14 days of duration) diarrhea remains a massive challenge. Here, we use a case-control study to decipher if fecal gut microbiota compositional differences between Ethiopian children with acute (n=554) or prolonged/persistent (n=95) diarrhea and frequency-matched non-diarrheal controls (n=663) are linked to diarrheal etiology.
View Article and Find Full Text PDFJ Infect Dis
August 2024
Department of Epidemiology, Emory Rollins School of Public Health, Atlanta, GA 30322, United States.
Attributing infectious causes of diarrhea is critical to inform treatment and burden estimates. The attributable fraction (AF) approach based on the association between pathogen quantity and diarrhea has been frequently used but may underestimate incidence. We leveraged data from the multisite birth-cohort Malnutrition and Enteric Disease (MAL-ED) Study, where diarrheal and non-diarrheal stools were collected from 1,715 children from 0-2 years.
View Article and Find Full Text PDFFront Public Health
April 2024
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Qatar Med J
November 2023
Pediatric allergy and clinical immunology, The Royal Hospital. Muscat-Oman Email:
Chronic giardia infection can lead to non-erosive gastrointestinal disorders, including protein-losing enteropathy (PLE). This report describes non-diarrheal PLE in chronic giardiasis in children with defective humoral immunity. Methods: The retrospective report is related to 2 children known to have a monogenic inborn error of immunity.
View Article and Find Full Text PDFMicroorganisms
November 2023
Groupe de Recherche Action en Santé (GRAS), Ouagadougou 06 BP 10248, Burkina Faso.
The estimates of enterotoxigenic (ETEC) and burden in developing countries are limited by the lack of rapid, accessible, and sensitive diagnostics and surveillance tools. We used a "Rapid LAMP based Diagnostic Test (RLDT)" to detect ETEC and in diarrheal and non-diarrheal stool samples from a 12-month longitudinal cohort of children under five years of age in a peri-urban area of Ouagadougou in Burkina Faso (West Africa). To allow comparison with the RLDT- results, conventional culture methods were used to identify strains in the stool samples.
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