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[Virus-Like Particles Carrying HIV-1 Env with a Modulated Glycan Composition].
Mol Biol (Mosk)
December 2024
Gamaleya Federal Research Center of Epidemiology and Microbiology, Moscow, 123098 Russia.
Previously obtained highly immunogenic Env-VLPs ensure overcoming the natural resistance of HIV-1 surface proteins associated with their low level of incorporation and inaccessibility of conserved epitopes to induce neutralizing antibodies. We also adopted this technology to modify Env trimers of the ZM53(T/F) strain to produce Env-VLPs by recombinant vaccinia viruses (rVVs). For VLP production, rVVs expressing Env, Gag-Pol (HIV-1/SIV), and the cowpox virus hr gene, which overcomes the restriction of vaccinia virus replication in CHO cells, were used.
View Article and Find Full Text PDFZoonoses in dog and cat shelters in North-East Italy: update on emerging, neglected and known zoonotic agents.
Front Vet Sci
November 2024
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Introduction: Shelters for stray dogs and cats deserve careful monitoring for zoonotic risk, as they represent a crucial point for prevention and control of infection spread. Data sorting to prioritize zoonotic agents in a geographic area need constant updating, but no regular official programs are ongoing, to allow an efficient risk survey for these animal species. This study aimed to conduct a comprehensive investigation of the prevalence of certain known, potential and emerging zoonoses within the framework of the routine monitoring of dog and cat shelters in North-East Italy.
View Article and Find Full Text PDFPoxvirus Epidemiology.
Methods Mol Biol
December 2024
Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Article Synopsis
- Poxviruses, especially those in the orthopoxvirus genus, have caused significant health issues throughout history, with smallpox being a prominent example.
- Smallpox, caused by the Variola virus, was successfully eradicated in 1980, marking a milestone in public health and requiring extensive research on orthopoxviruses.
- The text explores both historical and current epidemiology of poxvirus infections, focusing on significant viruses like Monkeypox and Vaccinia.
Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses.
Antiviral Res
January 2025
Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany. Electronic address:
Article Synopsis
- Monkeypox virus (MPXV) caused a significant outbreak in 2022, with over 90,000 cases and 181 fatalities, exhibiting signs of evolution and adaptation to hosts.
- Research revealed that different MPXV isolates from the Franconia region have mutations affecting their replication capabilities, particularly a variant with a mutation (D616L) that shows faster viral replication.
- The study also found that dihydroorotate dehydrogenase (DHODH) inhibitors are effective against MPXV and related viruses, offering promising low-toxicity options for future antiviral drug development.
A label-free optical biosensor-based point-of-care test for the rapid detection of Monkeypox virus.
Biosens Bioelectron
February 2025
Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, CA, 92093, USA. Electronic address:
Diagnostic approaches that combine the high sensitivity and specificity of laboratory-based digital detection with the ease of use and affordability of point-of-care (POC) technologies could revolutionize disease diagnostics. This is especially true in infectious disease diagnostics, where rapid and accurate pathogen detection is critical to curbing the spread of disease. We have pioneered an innovative label-free digital detection platform that utilizes Interferometric Reflectance Imaging Sensor (IRIS) technology.
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