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Background: Antidepressant drug treatment may be associated with weight gain, but long-term studies are lacking.
Methods: We included 3,127 adults (1,701 women) from the REGICOR study, aged 55.6 (SD = 11.
Unlabelled: Neural crest cells (NCCs) are a multipotent embryonic cell population of ectodermal origin that extensively migrate during early development and contribute to the formation of multiple tissues. Cardiac NCCs play a critical role in heart development by orchestrating outflow tract septation, valve formation, aortic arch artery patterning, parasympathetic innervation, and maturation of the cardiac conduction system. Abnormal migration, proliferation, or differentiation of cardiac NCCs can lead to severe congenital cardiovascular malformations.
View Article and Find Full Text PDFA Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized Double-Blind Clinical Trial.
Drug Des Devel Ther
December 2024
Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.
Article Synopsis
- The study investigates the effectiveness of esketamine as an adjunct to propofol sedation compared to sufentanil during minimally invasive rotary resection (MIRR) for breast tumors.
- Results show that patients receiving esketamine-propofol experienced significantly lower hypoxia rates (17.5%) and fewer airway interventions compared to those on sufentanil-propofol (39%).
- Overall, esketamine improves safety without affecting awakening time or patient satisfaction, making it a promising option for anesthesia during breast MIRR.
Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety.
Npj Ment Health Res
November 2024
Weill Cornell Medicine, New York, NY, USA.
Despite the high correlation between anxiety and depression, little remains known about the course of each condition when presenting concurrently. This study aimed to identify longitudinal patterns during antidepressant treatment in patients with depression and anxiety, and evaluate related factors associated with these patterns. By analyzing longitudinal self-report Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) scores that tracked courses of depression and anxiety over a three-month window among the 577 adult participants, six depression and six anxiety trajectory subgroups were computationally derived using group-based trajectory modeling.
View Article and Find Full Text PDFPsychotropic use for behavioral and psychological symptoms of dementia during the COVID-19 pandemic: a systematic review and meta-analysis.
BMC Geriatr
November 2024
University of Maryland School of Nursing, Baltimore, MD, 21201, USA.
Background: During the COVID-19 pandemic, the provision of quality care for behavioral and psychological symptoms in older adults with dementia may have been impeded due to physical distancing and infection control measures. Of particular concern is whether psychotropic medication use has increased despite its limited efficacy and adverse effects. This systematic review described the trajectory of psychotropic use for older adults with dementia across various settings, from community living to healthcare settings during the pandemic.
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