Rationale: Cutaneous metastasis of testicular choriocarcinoma is exceptionally uncommon. To our knowledge, only 14 cases have been reported in the past 10 years in the pubmed. We have an uncommon case of testicular choriocarcinoma who has metastasized to the adjacent skin and organ systems.
Patient Concerns: An 18-year-old male was diagnosed with initial presentation of cutaneous mass at the left back. Followly,biopsy was performed under local anesthesia.Histopathological examination was consistent with the diagnosis of metastatic choriocarcinoma.
Diagnoses: The histopathological assessment of the biopsied tissue, in combination with elevated serum β-HCG levels and presentation of testicular mass, indicated primary testicular choriocarcinoma with cutaneous and systemic metastasis.
Interventions: Subsequently radical orchiectomy was performed.
Outcomes: Despite the case completed one cycle of cisplatin-based regimen chemotherapy, he died of multiple organ dysfunction syndrome 2 months after surgery.
Lessons: In this report, cutaneous metastasis with testicular choriocarcinoma is extremely rare. It is important to recognize that this unusual variant of testicular choriocarcinoma has the potential to behave aggressively and to metastasize.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392768 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000010736 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[A Case of Intestinal Metastasis of Testicular Choriocarcinoma Revealed Through Gastrointestinal Bleeding].
Hinyokika Kiyo
November 2024
The Department of Urology, Hiroshima Prefectural Hospital.
A 26-year-old male presented to a hospital with complaints of hemoptysis and right scrotal swelling. Computed tomography (CT) revealed right testicular swelling, multiple lung metastases, and small intestinal wall thickening. The patient's β-human chorionic gonadotropin, alpha-fetoprotein, lactate dehydrogenase, and hemoglobin levels were 103.
View Article and Find Full Text PDFComparative analysis of testicular and nontesticular choriocarcinoma: a population-based study.
Ann Med Surg (Lond)
December 2024
Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Background: Germ cell tumors (GCTs) are common solid tumors in young men, originating in the testicles or outside the gonads. Choriocarcinoma, a rare and aggressive subtype, primarily affects females but can also occur in males. Treatment options depend on the stage and location of the tumor, with early recognition being crucial for better outcomes.
View Article and Find Full Text PDFHuman chorionic gonadotropin (hCG) has structural similarities with thyroid-stimulating hormone (TSH) and may stimulate TSH receptors at higher concentrations. During pregnancy, placental hCG causes TSH suppression, contributing to hyperemesis. However, in males, clinical manifestations caused by excess hCG are rare.
View Article and Find Full Text PDFStereotactic Radiosurgery for Choriocarcinoma Brain Metastases: Illustrative Case Presentation and Systematic Review.
World Neurosurg
November 2024
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA. Electronic address:
Background: Choriocarcinoma (CC) is a rare and aggressive form of germ cell tumor. There is limited evidence describing clinical outcomes in patients with primary CC and brain metastases (BM). Only a few single case reports have documented the use of stereotactic radiosurgery (SRS) for CC BM.
View Article and Find Full Text PDFEpithelioid trophoblastic tumor in male patients with germ cell tumor: A clinicopathologic analysis of five cases.
Hum Pathol
November 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:
Article Synopsis
- Epithelioid trophoblastic tumor (ETT) is a rare type of tumor found in the testis, with only seven cases documented before this study, which adds five more cases from a single institution, making it the largest series reported.
- The patients had a mean age of 44, and most had prior testicular germ cell tumors treated with chemotherapy; ETT appeared in metastatic sites many years later, and its diagnosis was often associated with unusual histological features that can resemble other types of cancer.
- Despite treatment, the outcomes were poor, with two patients dying within 17 months of diagnosis and three others remaining alive with metastatic disease averaging 20 months post-diagnosis, highlighting the aggressive nature of ETT.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!