Water proton NMR detection of amide hydrolysis and diglycine dimerization.

Chem Commun (Camb)

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA.

Published: June 2018

The transverse relaxation rate of water protons R2(1H2O) is found to be sensitive to amide hydrolysis and diglycine dimerization. The results demonstrate the feasibility of using R2(1H2O) as a diagnostic tool to detect chemical changes in aqueous solutions. Potential applications include drug product formulation and inspection.

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Source
http://dx.doi.org/10.1039/c8cc03935fDOI Listing

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