Ranolazine for Angina in Hypertrophic Cardiomyopathy.

Case Rep Cardiol

Department of Cardiology, Hackensack University Medical Center, Hackensack, NJ, USA.

Published: April 2018

Ranolazine is an antianginal and works by inhibiting late-sodium current (). However, its use is limited mostly to patients with coronary artery disease. However, literature has shown its potential benefit in relieving angina in hypertrophic cardiomyopathy. Hereby, we discuss two cases where ranolazine led to improvement in angina refractory to beta-blockers. In conclusion, ranolazine can be considered as a potential antianginal drug in patients with hypertrophic cardiomyopathy refractory to beta-blockers.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925191PMC
http://dx.doi.org/10.1155/2018/5142572DOI Listing

Publication Analysis

Top Keywords

hypertrophic cardiomyopathy
12
angina hypertrophic
8
refractory beta-blockers
8
ranolazine
4
ranolazine angina
4
cardiomyopathy ranolazine
4
ranolazine antianginal
4
antianginal works
4
works inhibiting
4
inhibiting late-sodium
4

Similar Publications

The Role of RyR2 Mutations in Congenital Heart Diseases: Insights Into Cardiac Electrophysiological Mechanisms.

J Cardiovasc Electrophysiol

January 2025

Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Ryanodine receptor 2 (RyR2) protein, a calcium ion release channel in the sarcoplasmic reticulum (SR) of myocardial cells, plays a crucial role in regulating cardiac systolic and diastolic functions. Mutations in RyR2 and its dysfunction are implicated in various congenital heart diseases (CHDs). Studies have shown that mutations in the RYR2 gene, which encodes the RyR2 protein, are linked to several cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), calcium release deficiency syndrome (CRDS), and atrial fibrillation (AF).

View Article and Find Full Text PDF

Background And Aims: Hypertrophic cardiomyopathy (HCM) has various aetiologies, including genetic conditions like Fabry disease (FD), a lysosomal storage disorder. FD prevalence in high-risk HCM populations ranges from 0.3% to 11.

View Article and Find Full Text PDF

Cardiac amyloidosis represents a unique disease process characterized by amyloid fibril deposition within the myocardial extracellular space. Advances in multimodality cardiac imaging enable accurate diagnosis and facilitate prompt initiation of disease-modifying therapies. Furthermore, rapid advances in multimodality imaging have enriched understanding of the underlying pathogenesis, enhanced prognostication, and resulted in the development of imaging-based markers that reflect the amyloid burden, which is of increasing importance when assessing the response to treatment.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!