AI Article Synopsis
- Colombian traditional medicine has utilized the aerial parts of certain plants for their anti-inflammatory effects, though the mechanisms behind this were previously unclear.
- The study focused on hydroalcoholic extracts from three different plants and their effects on LPS-stimulated macrophages, assessing inflammatory markers and antioxidant activity.
- Findings revealed that all extracts reduced inflammation-related compounds, with HETK being particularly effective, indicating their potential as natural treatments for inflammation-related diseases.
Article Abstract
Aerial parts of , and have been used in Colombian traditional medicine for inflammation. However, the underlying mechanisms that could explain the anti-inflammatory actions remain unknown. This study aimed to elucidate the anti-inflammatory and cytoprotective effects of hydroalcoholic extracts from (HECC), (HETK), and (HEPS) in LPS-stimulated THP-1 macrophages. Reactive oxygen species (ROS), nitric oxide (NO), and malondialdehyde (MDA) were monitored as inflammatory and oxidative markers. The inhibition of lipoxygenase (LOX) and cyclooxygenase (COX) activities in a cell-free system were also investigated. Antioxidant activities were determined using standard methods. All extracts inhibited the NO, ROS, and MDA levels. HETK showed the highest ROS production inhibition and the highest antioxidant values, whereas HETK and HEPS significantly decreased the cytotoxicity mediated by LPS. The release of MDA was reduced significantly by all extracts. Moreover, the catalytic activity of LOX was inhibited by HECC and HETK. HECC was a more potent reducer of COX-2 activity. All extracts effectively suppressed COX-1 activity. In summary, these results suggest that HECC, HEPS, and HETK possess anti-inflammatory properties. Therefore, these plants could provide a valuable source of natural bioactive compounds for the treatment of inflammatory-related diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941728 | PMC |
| http://dx.doi.org/10.1155/2018/1953726 | DOI Listing |
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