A 79-year-old female called 911 for abdominal pain in her left upper quadrant with radiation through to her back and left shoulder for three hours. Upon arrival to the emergency department her physical exam was positive only for tenderness in the left upper quadrant of her abdomen. The patient denied any history of trauma but reported she "did sneeze three times" just prior to the onset of her pain. Computed tomography angiography of the abdomen and pelvis was obtained to evaluate for vascular pathology. The radiologist immediately called with concern for splenic laceration. The general surgeon took the patient directly to the operating room where she underwent a splenectomy and recovered without sequelae. This is the first case report of spontaneous splenic rupture that resulted after the act of sneezing. It is important to be aware of this rare clinical entity because early recognition can be life saving.
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http://dx.doi.org/10.5811/cpcem.2017.2.32847 | DOI Listing |
Int J Surg Case Rep
January 2025
Faculty of Medicine and Health Sciences, Omdurman Islamic University, Sudan.
Introduction: Spontaneous rupture of the pathological malarial spleen (SRPMS) is a rare condition with a mortality rate among travelers of approximately 38 %, whereas it was around 10 % for local citizens. The mortality rate for overwhelming post-splenectomy sepsis was reported to be about 50 %.
Methods: A retrospective study was conducted from febraury2022 to July 2022.
Int J Surg Case Rep
January 2025
School of Postgraduate Studies and Research, Amoud University, Amoud Valley, Borama 25263, Somalia.
Introduction: Spontaneous splenic rupture (SSR) is a rare, life-threatening complication, sometimes associated with infections like malaria and dengue fever. This case report details a unique presentation of SSR.
Case Presentation: A 28-year-old male in Somalia presented with fever, epigastric pain, nausea, vomiting, and body aches, consistent with malaria and dengue.
Radiol Case Rep
February 2025
Department of Radiology, Chikamori Hospital, Kochi, Japan.
Torsion of an accessory spleen is a rare condition, and it is often difficult to diagnose. It frequently presents as an acute abdomen, especially in young individuals. Only several dozen cases have been reported so far, and instances of rupture are even rarer.
View Article and Find Full Text PDFJ Vet Diagn Invest
December 2024
California National Primate Center, University of California-Davis, Davis, CA, USA.
Lymphoproliferative disorders of natural killer (NK)-cell lineage are well documented in humans but have yet to be documented in non-human primates (NHPs). Here we describe a case of NK-cell lymphoproliferative disorder/leukemia in a 20-y-old captive female rhesus macaque (). The animal clinically had mild splenomegaly and marked lymphocytosis with small-to-medium lymphocytes in blood smears.
View Article and Find Full Text PDFOrphanet J Rare Dis
December 2024
Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China.
Background: Nuclear receptor subfamily 5 group A member 1 (NR5A1) plays pivotal roles in steroidogenesis and gonadal development. 46, XY disorder of sexual development (DSD) caused by NR5A1 mutations is a rare genetic condition. This study aimed to provide a comprehensive analysis of the clinical characteristics and molecular defects observed in 19 Chinese patients with NR5A1 variants, including assessing the deleterious effects of novel variants in vitro and evaluating their functional impact on the gonad and adrenal glands in vivo.
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