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Natural Molecule-Derived Nanogels from Hematoxylin and l-lysine for Biomedical Use with Antimicrobial Properties.
Int J Mol Sci
December 2024
Department of Chemistry, Faculty of Sciences, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.
Hematoxylin (HT) is a natural staining dye used in histopathology, often combined with Eosin for H&E staining. A poly(hematoxylin-co-l-lysine) (p(HT-co-l)) nanonetwork was synthesized through a one-step Mannich condensation reaction using formaldehyde as a linking agent. The resulting p(HT-co-l) nanogels had an average size of about 200 nm and exhibited a smooth surface and desirable functional groups such as -OH, -NH, and -COOH, as recognized by FT-IR analysis.
View Article and Find Full Text PDFHyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo.
Biomacromolecules
December 2024
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
Acyclovir (ACV) is a potentially effective antiviral medication; however, it has a serious drawback, which is its poor solubility, bioavailability, and short half-life. The goal of this study is to improve its drawbacks through the synthesis of nanogels. In this study, the cross-linked hyaluronic acid-grafted poly(acrylamide--itaconic acid) nanogel is synthesized successfully through free radical polymerization and used as a safe pH-responsive carrier for ACV.
View Article and Find Full Text PDFUltrasound-Triggered Nanogel Boosts Chemotherapy and Immunomodulation in Colorectal Cancer.
ACS Appl Mater Interfaces
January 2025
Department of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Chemotherapy is the primary therapy for colorectal cancer. However, its efficacy has been limited by chemoresistance, which is mainly caused by inadequate intratumoral drug accumulation and immunosuppressive microenvironments. To address these limitations, we developed a low-intensity ultrasound (LIU)-controlled and charge-reversible nanogel (R-NG), utilizing conjugated chitosan-polypyrrole polymers linked via thioketal bonds, with TiO absorbed onto its surface.
View Article and Find Full Text PDFOxaliplatin-loaded amphiphilic hyaluronic acid nanohydrogel formed via interfacial reactions enhances the therapeutic effect of targeted tumor.
Int J Biol Macromol
January 2025
School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address:
Hyaluronic acid (HA) nanogels have attracted widespread attention, aiming to improve cancer treatment paradigms and overcome the limitations of free-form drugs. However highly hydrophilic nature of HA nanogels limits their potential application where amphiphilic interactions are required for the delivery of hydrophobic drugs. In this study, we developed amphiphilic structure oxaliplatin (OXA) loaded oligo-hyaluronic acid (oHA)-PEG-Octane nanogel using stable disulfide bonds with ultrasonic re-emulsion method.
View Article and Find Full Text PDFEnhanced anti-bacterial properties and thermal regulation via photothermal conversion with localized surface plasmon resonance effect in cotton fabrics.
J Colloid Interface Sci
March 2025
Zhejiang Provincial Engineering Research Center for Green and Low-carbon Dyeing & Finishing, Key Laboratory of Advanced Textile Materials & Manufacturing Technology, Ministry of Education, Zhejiang Sci-Tech University, 310018 Hangzhou, China; Technical University of Munich, TUM School of Natural Sciences, Department of Physics, Chair for Functional Materials, James-Franck-Str. 1, 85748 Garching, Germany. Electronic address:
Enhanced anti-bacterial properties and thermal regulation are realized in cotton fabrics cross-linked with hybrid poly(di(ethylene glycol) methyl ether methacrylate-co-oligo(ethylene glycol) methyl ether methacrylate-co-ethylene glycol methacrylate) nanogels containing gold nanoparticles (Au NPs), denoted as hybrid P(MA-co-MA-co-EGMA)/Au nanogels. Pure P(MA-co-MA-co-EGMA) nanogels are synthesized by emulsion polymerization as carriers and then embedded with Au NPs via in-situ reduction. By applying 1,2,3,4-butanetetracarboxylic acid as a cross-linker and changing the amount of hybrid P(MA-co-MA-co-EGMA)/Au nanogels in solution, the weight gain ratios of hybrid nanogels on cotton fabrics are set as 10 % (CHN-10) and 20 % (CHN-20).
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