AI Article Synopsis
- Selenium is important for thyroid hormone regulation, and this study investigates its link to subclinical hypothyroidism using data from over 14,000 Brazilian adults aged 35-74.
- Subclinical hypothyroidism was identified in 5.4% of participants, categorized by specific thyroid hormone levels without medication for thyroid disease.
- Higher selenium intake was inversely associated with subclinical hypothyroidism, with lower odds in the second and third tertiles of selenium consumption, suggesting more research is needed for accurate dietary assessment.
Article Abstract
Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto-ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35⁻74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of >4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval [CI], 3.8⁻7.0%). Compared with the first tertile of Se intake, the second (odds ratio [OR], 0.79; 95% CI, 0.65⁻0.96%) and third (OR, 0.72; 95% CI, 0.58⁻0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024881 | PMC |
| http://dx.doi.org/10.3390/nu10060693 | DOI Listing |
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