AI Article Synopsis
- - The study analyzed 22 patients with EGFR mutation-positive non-small cell lung cancer who developed resistance to 1st/2nd generation EGFR inhibitors, focusing on the use of liquid biopsies and re-biopsies to detect mutations.
- - Detection rates for the T790M mutation were 52% using re-biopsy and 58% with liquid biopsy, with a 58% concordance rate between the two methods, highlighting variability in effectiveness across different metastatic lesions.
- - The conclusion suggests that while liquid biopsies provide a comprehensive view of the body's mutations, re-biopsies are better for localized diagnosis; using both methods together can enhance treatment strategies for patients.
Article Abstract
Background/aim: The purpose of this study was to consider appropriate application of liquid and re-biopsy through analysis of current status in practice.
Patients And Methods: We performed a retrospective analysis of 22 patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer who exhibited 1st/2nd generation EGFR-tyrosine kinase inhibitors resistance. The cobas® method was used to detect T790M with re-biopsy and the mutation-biased PCR and quenched probe method was used with liquid biopsy.
Results: T790M detection rate was 52% with re-biopsy and 58% with liquid biopsy. The concordance between tissue and plasma was 58%. One patient who was T790M-positive with liquid biopsy showed heterogeneity among metastatic lesions in terms of osimertinib efficacy, as revealed by T790M detection with re-biopsy.
Conclusion: Liquid biopsy reflects the whole body, whereas re-biopsy is useful for spatial diagnosis. Considering these characteristics, a combination of liquid and re-biopsy contribute to enhanced treatment.
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| http://dx.doi.org/10.21873/anticanres.12628 | DOI Listing |
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