Background/aim: In the use of paclitaxel, side-effects caused by itself or solubilizing agents have become a major obstacle. In this study we aimed to synthesize biocompatible and degradable compounds for micelles to be used as carriers for paclitaxel.
Materials And Methods: Methoxypolyethylene glycol-lactate was obtained from methyl lactate and methoxypolyethylene glycol having a molecular weight of 350. Monoalkoxy phosphoryl chlorides were obtained from phosphoryl chloride and four kinds of linear alcohols. Then, four kinds of alkyl di(methoxypolyethylene glycol-lactate) phosphates were obtained from them.
Results: The results of 1H NMR spectroscopy showed that alkyl di(methoxypolyethylene glycol-lactate) phosphates were successfully synthesized. When 1-dodecanol, 1-hexadecanol, 1-octadecanol, and 1-eicosanol were used as side chains, the yields were 73.5±4.2, 69.1±3.6, 72.2±2.8, and 71.8±3.7%, respectively. The spectrum of 31P NMR suggested the existence of optical isomers.
Conclusion: Four kinds of phosphoester compounds for micelle preparations were synthesized using lactic acid.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.21873/anticanres.12607 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phosphoester bond hydrolysis by a discrete zirconium-oxo cluster: mechanistic insights into the central role of the binuclear Zr-Zr active site.
Chem Sci
October 2024
Department of Chemistry, KU Leuven Celestijnenlaan 200F Leuven 3001 Belgium
Effective degradation of non-natural phosphate triesters (PTs) widely used in pesticides and warfare agents is of paramount relevance for human and environmental safety, particularly under acidic conditions where they are highly stable. Here, we present a detailed reactivity and mechanistic study pioneering discrete {ZrO} clusters, which are commonly employed as building blocks for Zr-MOFs and as non-classical soluble coordination compounds for the degradation of PTs using the pesticide ethyl paraoxon as a model. Combined computational studies, mechanistic experiments, and EXAFS analysis show that the reactivity of these clusters arises from their Zr-Zr bimetallic sites, which hydrolyze ethyl paraoxon under acidic conditions through an intramolecular pathway.
View Article and Find Full Text PDFDissolved organic phosphorus bond-class utilization by Synechococcus.
FEMS Microbiol Ecol
August 2024
Department of Molecular and Cellular Biology, University of Arizona, 1007 East Lowell Street, Tucson, Arizona, AZ 85721, United States.
Dissolved organic phosphorus (DOP) contains compounds with phosphoester, phosphoanhydride, and phosphorus-carbon bonds. While DOP holds significant nutritional value for marine microorganisms, the bioavailability of each bond-class to the widespread cyanobacterium Synechococcus remains largely unknown. This study evaluates bond-class specific DOP utilization by Synechococcus strains from open and coastal oceans.
View Article and Find Full Text PDFRecovery of an Antioxidant Derived from a Phenolic Diphosphite from Wastewater during the Production of a Polypropylene Compound: A Step towards Sustainable Management.
Molecules
June 2024
Research Group GIA, Comfenalco Technological University Foundation, Cartagena 30015, Colombia.
Organic phosphoester (OPE) antioxidants are currently required due to their contribution to enhancing the quality of polymers, including polypropylene (PP). In this research, an integral methodology is presented for the efficient extraction of bis(2,4-dicumylphenyl) pentaerythritol diphosphite from industrial wastewater. Upon employing the solid-phase extraction (SPE) technique, the recovered compound is subjected to a comprehensive analysis of the recovered compound using high-performance liquid chromatography (HPLC), mass spectrometry (MS), thermal analysis (TGA), Fourier transforms infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC).
View Article and Find Full Text PDFMicrobial phosphorus-cycling genes in soil under global change.
Glob Chang Biol
April 2024
State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, Centre for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, China.
The ongoing climate change on the Tibetan Plateau, leading to warming and precipitation anomalies, modifies phosphorus (P) cycling in alpine meadow soils. However, the interactions and cascading effects of warming and precipitation changes on the key "extracellular" and "intracellular" P cycling genes (PCGs) of bacteria are largely unknown for these P-limited ecosystems. We used metagenomics to analyze the individual and combined effects of warming and altered precipitation on soil PCGs and P transformation in a manipulation experiment.
View Article and Find Full Text PDFBrazilin-Ce nanoparticles attenuate inflammation by de/anti-phosphorylation of IKKβ.
Biomaterials
March 2024
State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, School of Life Sciences and Technology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China. Electronic address:
Inflammation is associated with a series of diseases like cancer, cardiovascular disease and infection, and phosphorylation/dephosphorylation modification of proteins are important in inflammation regulation. Here we designed and synthesized a novel Brazilin-Ce nanoparticle (BX-Ce NPs) using Brazilin, which has been used for anti-inflammation in cardiovascular diseases but with narrow therapeutic window, and Cerium (IV), a lanthanide which has the general activity in catalyzing the hydrolysis of phosphoester bonds, to conferring de/anti-phosphorylation of IKKβ. We found that BX-Ce NPs specifically bound to Asn225 and Lys428 of IKKβ and inhibited its phosphorylation at Ser181, contributing to appreciably anti-inflammatory effect in cellulo (IC = 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!