AI Article Synopsis
- - The study focuses on how mTOR inhibitors (mTORis) impact the expression of proteins related to the mTOR pathway in cutaneous squamous-cell carcinomas (SCC) in organ-transplant recipients (OTR), who often face skin tumor issues while on immunosuppressants.
- - Researchers conducted an immunohistochemical analysis on 23 SCC samples, comparing their protein expression patterns before and after the patients switched to mTORis, examining for markers like pAkt, pmTOR, and PI3K.
- - The findings revealed that switching to mTORis did not lead to significant changes in the expression levels of key proteins (pmTOR, PI3K, pAkt) involved in the mTOR
Article Abstract
Background/aim: Inhibitors of the mammalian target of rapamycin (mTORis) exert immunosuppressive and antitumor effects and are used in organ-transplant recipients (OTR) as immunosuppressants able to reduce skin tumor burden. This study investigated the effects of mTORis on the expression of mTOR pathway proteins in cutaneous squamous-cell carcinomas (SCC) developing in OTR, before and after switching to mTORis.
Materials And Methods: An immunohistochemical study was performed on 23 SCC sections excised from OTR with post-transplant SCC, before or after switch to mTORis, with antibodies against pAkt, pmTOR and PI3K.
Results: pmTOR expression was found in 8/12 SCC pre-switch, and in 8/11 SCC post-switch, to mTORis. All (but 2) SCC expressed PI3K, and all SCCs expressed pAkt.
Conclusion: mTORis do not significantly change the immunohistochemical expression of molecules upstream of the mTOR inhibition (pmTOR, PI3K, pAkt), in cutaneous SCC.
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| http://dx.doi.org/10.21873/anticanres.12597 | DOI Listing |
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