Combination Therapy with Glucan and Coenzyme Q in Murine Experimental Autoimmune Disease and Cancer.

Background/aim: Coenzyme Q is a well-accepted anti-oxidant agent known to play a protective role in various physiological and disease processes. Recently, Coenzyme Q is gaining attention as a substance with significant anti-inflammatory properties. β-Glucan is the most studied immunomodulator with significant synergetic effects with numerous bioactive molecules. We aimed to evaluate the possible synergistic effects of simultaneous use of coenzyme Q with the well-established immune modulator, β-glucan, on immune reactions and cancer development.

Materials And Methods: Coenzyme Q and β-glucan were used, both in vivo and in vitro, and their effects were evaluated using phagocytosis and cytokine secretion.

Results: Our study confirmed the strong anti-inflammatory effects of coenzyme Q and showed that these effects were further potentiated with the addition of β-glucan. The anticancer effects of coenzyme Q were less pronounced, but stronger, with the addition of β-glucan.

Conclusion: There is significant synergy between coenzyme Q and β-glucan.