The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complexes (SWRs), which contribute to hippocampal memory formation, to investigate MC involvement in this fundamental population activity. We find that a significant fraction of MCs (∼47%) is recruited into the active neuronal network during SWRs in the CA3 area. Moreover, MCs receive pronounced, ripple-coherent, excitatory and inhibitory synaptic input. Finally, we find evidence for SWR-related synaptic activity in granule cells that is mediated by MCs. Given the widespread connectivity of MCs within and between hippocampi, our data suggest a role for MCs as a hub functionally coupling the CA3 and the DG during ripple-associated computations.
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Article Synopsis
- Researchers explored how glutamatergic mossy cells (MCs) in the dentate gyrus (DG) connect to granule cells (GCs), using optogenetics to activate MC axons specifically.
- They found that this optogenetic stimulation could elicit field excitatory postsynaptic potentials (fEPSPs) in GCs in the inner molecular layer (IML), which were consistent across the DG.
- The fEPSPs recorded were relatively weak, showing low amplitude and minimal population spikes, indicating that the MC input to GCs is generally weak but widespread throughout the granule cell population.
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