Narcissistic personality disorder (NPD) is associated with both seeming indifference and hypersensitivity to social feedback. This study evaluated whether rejection sensitivity and empathic difficulties in NPD are accounted for by altered facial emotion recognition (FER). Two-hundred non-clinical individuals self-reported NPD features, rejection sensitivity, and empathy and performed an FER task assessing the ability to determine the presence or absence of an emotion when viewing neutral and negative facial stimuli presented at varying emotional intensities (25%, 50%, 75%). Those with higher NPD features were faster at accurately recognizing neutral and low, 25%-intensity emotional stimuli. This response pattern mediated the association between NPD features and increased anger about rejection. Thus, individuals with high NPD traits are hypervigilant toward subtle negative emotions and neutral expressions; this may explain their tendency to experience intense angry feelings when facing the possibility that the others would not meet their need for acceptance.
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http://dx.doi.org/10.1521/pedi_2018_32_350 | DOI Listing |
Mol Psychiatry
January 2025
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
This study investigated the relationship between gut microbiota and neuropsychiatric disorders (NPDs), specifically anxiety disorder (ANXD) and/or major depressive disorder (MDD), as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV or V criteria. The study also examined the influence of medication use, particularly antidepressants and/or anxiolytics, classified through the Anatomical Therapeutic Chemical (ATC) Classification System, on the gut microbiota. Both 16S rRNA gene amplicon sequencing (16S) and shallow shotgun sequencing (WGS) were performed on DNA extracted from 666 fecal samples from the Tulsa-1000 and Neurocomputational Mechanisms of Affiliation and Personality Study Center for Biomedical Research Excellence (NeuroMAP CoBRE) cohorts.
View Article and Find Full Text PDFAdv Mater
December 2024
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Magnetoplumbites are one of the most broadly studied families of hexagonal ferrites, typically with high magnetic ordering temperatures, making them excellent candidates for permanent magnets. However, magnetic frustration is rarely observed in magnetoplumbites. Herein, the discovery, synthesis, and characterization of the first Mn-based magnetoplumbite, as well as the first magnetoplumbite involving pnictogens (Sb), ASbMnO (A = K or Rb) are reported.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Delivering medical agents to diseased tissues has been challenging, leading researchers to study the in vivo transport process in the body for improving delivery. Many imaging techniques exist for mapping the distribution of medical agent-carrying nanoparticles in tissues, but they cannot capture the three-dimensional context of tissues with single nanoparticle resolution. Here, we developed 3DEM-NPD, a three-dimensional electron microscopy (3D EM) machine learning strategy to image and map single nanoparticle distributions (NPD) in tissues.
View Article and Find Full Text PDFJ Biosci Bioeng
November 2024
Bio Process Research and Development Laboratories, Manufacturing Division, Kyowa Kirin Co., Ltd., Takasaki, Gunma 370-0013, Japan.
The multi-attribute method (MAM) has been recognized as an optimal tool for quality control in biotherapeutics. New peak detection (NPD) is one of the functions of MAM for detecting unexpected differences in samples and is an essential feature required for replacing conventional methods with MAM. Not only used for release and stability testing, NPD is also considered valuable for evaluating comparability and identifying product quality attributes in the research phase.
View Article and Find Full Text PDFInorg Chem
November 2024
College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China.
The hexagonal perovskite derivatives BaM'M″O featuring a hybrid structure composed of 9R hexagonal perovskite and palmierite structure motifs exhibit significant oxide ionic conductivity due to the highly disordered oxide-ion and M-cation sublattices. Herein, we report the structure and electrical properties of the perovskite BaTiWO. Three-dimensional (3D) electron diffraction (ED), neutron powder diffraction (NPD), and neutron pair distribution functions (nPDF) revealed a 9R hexagonal perovskite structure for BaTiWO with fully occupied central M2 sites, partially occupied outer M1 sites, and oxygen-deficient cubic c-BaO sublayers.
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