Since the opening for signature of the European Convention for the Protection of Animals Used for Experimental and Other Scientific Purposes in 1986, the European Pharmacopoeia Commission and its experts have carried out a programme of work committed to Replacing, Reducing and Refining (3Rs) the use of animals for test purposes. While updates on achievements in the field of the 3Rs are regularly provided, this article summarises the activities of the Ph. Eur. Commission in this field within the last decade.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Fit for purpose testing and independent GMP validation of the monocyte activation test.
Curr Res Toxicol
December 2024
Large Molecule Analytical Development, Janssen Biologics LLC (a Johnson and Johnson Company), 200 Great Valley Parkway, Malvern, PA 19355 USA.
The present study describes the "fit for purpose" testing and the independent product-specific GMP validation of the monocyte activation test (MAT) to detect pyrogenic and pro-inflammatory contaminants, MAT Method A, Quantitative Test (European Pharmacopoeia, Ph. Eur. chapter 2.
View Article and Find Full Text PDFDevelopment of a 50% (w/v) aluminium chloride hexahydrate solution as haemostatic agent.
Eur J Hosp Pharm
January 2025
Pharmacy Department, Hospices Civils de Lyon, Groupement Hospitalier Nord, Lyon, France
Objectives: Acceleration of the haemostasis process after dermatological surgery predominantly relies on mechanical methods, such as the use of sutures or staples. To our knowledge, there is currently no commercialised haemostatic agent for this specific application. Due to the protein precipitation properties of the 50% (w/v) aluminium chloride hexahydrate solution, its physicochemical stability and maintenance of sterility over a 6 month period were assessed.
View Article and Find Full Text PDFTraditional Uses, Bioactive Compounds, and New Findings on Pharmacological, Nutritional, Cosmetic and Biotechnology Utility of .
Nutrients
December 2024
Department of Medicinal Plant and Mushroom Biotechnology, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Cracow, Poland.
(L.) Medik. (shepherd's purse) is a medicinal plant recently introduced to European Pharmacopoeia.
View Article and Find Full Text PDFChanges in Growth and Metabolic Profile of Georgi in Response to Sodium Chloride.
Biology (Basel)
December 2024
Department of Pharmaceutical Biology and Biotechnology, Division Pharmaceutical Biology and Botany, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Georgi is a valuable medicinal plant of the family. Its roots have been used in Traditional Chinese Medicine (under the name Huang-qin) since antiquity and are nowadays included in Chinese and European Pharmacopoeias. It is abundant in bioactive compounds which constitute up to 20% of dried root mass.
View Article and Find Full Text PDFHepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors.
JHEP Rep
January 2025
Hepatitis Viruses and Pathobiology of Chronic Liver Diseases - LabEx DEVweCAN, Inserm U1052, Cancer Research Centre of Lyon - Hepatology Institute of Lyon F - IHU EVEREST, University of Lyon 1, ISPB, France, CNRS UMR5286, Centre Léon, Lyon, France.
Background & Aims: Owing to unexplained interpatient variation and treatment failure in hepatocellular carcinoma (HCC), novel therapeutic approaches remain an urgent clinical need. Hepatic neurons, belonging to the autonomic nervous system (ANS), mediate liver/whole body crosstalk. Pathological innervation of the ANS has been identified in cancer, nurturing tumor stroma and conferring stronger carcinogenic properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!