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CRISPR-Cas9 screening identifies the role of FER as a tumor suppressor.
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February 2025
Army Medical University, Chongqing, PR China.
It is important to systematically identify tumor suppressor genes (TSGs) to improve our understanding of tumorigenesis and develop strategies for early diagnosis and mitigating disease progression. In the present study, we used an in vivo genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) screen and identified FPS/FES-related (FER) as a TSG. Single-cell RNA sequencing (scRNA-seq) revealed that normal cells with low FER expression exhibited elevated malignant transformation potential and stemness properties.
View Article and Find Full Text PDFMeeting report: Society for Developmental Biology 83rd annual meeting.
Dev Growth Differ
January 2025
Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
Frequency and clinical characteristics of children and young people with type 2 diabetes at diagnosis from five world regions between 2012 and 2021: data from the SWEET Registry.
Diabetologia
January 2025
Department of Women's and Children's Health, Azienda Ospedaliero/Universitaria delle Marche, 'G. Salesi Hospital', Ancona, Italy.
Aims/hypothesis: The diagnosis of type 2 diabetes is increasing in young people worldwide. This study evaluated the frequency and clinical characteristics of young people presenting with type 2 diabetes from the multinational SWEET e.V Registry 2012-2021, including the first years of the COVID-19 pandemic.
View Article and Find Full Text PDFExamining the Performance of ChatGPT 3.5 and Microsoft Copilot in Otolaryngology: A Comparative Study with Otolaryngologists' Evaluation.
Indian J Otolaryngol Head Neck Surg
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Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS) Study Group, 75000 Paris, France.
Article Synopsis
- A study compared the performance of ChatGPT 3.5 and GPT-4 (Microsoft Copilot) in a public healthcare otolaryngology exam against actual specialist scores.
- The examination consisted of 135 questions, and GPT-4 scored 88.5 points while ChatGPT scored 60 points, highlighting significant differences in accuracy.
- GPT-4 ranked as the second-best performer among 108 candidates, while ChatGPT placed 83rd, demonstrating that GPT-4 has a better ability to answer medical questions accurately.
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