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Genetic associations with neural reward responsivity to food cues in children.
Front Nutr
September 2024
Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States.
Article Synopsis
- The study aimed to investigate how certain genetic factors related to obesity influence children's brain responses to food advertisements after eating.* -
- Researchers analyzed fMRI data from 151 children aged 9-12 and found that a specific genetic variant (rs9939609) was associated with increased brain activity in the lateral hypothalamus in response to food cues, although this result wasn't significant after correcting for multiple comparisons.* -
- The overall conclusion suggests that children with a genetic predisposition to obesity may exhibit stronger brain reward responses to food cues, which might lead to overeating.*
Corrigendum: Differential neural reward reactivity in response to food advertising medium in children.
Front Neurosci
March 2023
Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States.
[This corrects the article DOI: 10.3389/fnins.2023.
View Article and Find Full Text PDFDifferential neural reward reactivity in response to food advertising medium in children.
Front Neurosci
February 2023
Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States.
Introduction: Food cues including food advertisements (ads) activate brain regions related to motivation and reward. These responses are known to correlate with eating behaviors and future weight gain. The objective of this study was to compare brain responses to food ads by different types of ad mediums, dynamic (video) and static (images), to better understand how medium type impacts food cue response.
View Article and Find Full Text PDFGenome-Wide CRISPR Off-Target DNA Break Detection by the BLISS Method.
Methods Mol Biol
March 2021
Science for Life Laboratory (SciLifeLab), Research Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Clustered regularly interspaced palindromic repeat (CRISPR) systems are revolutionizing many areas of biology and medicine, where they are increasingly utilized as therapeutic tools for correcting disease-causing mutations. From a clinical perspective, unintended off-target (OT) DNA double-strand break (DSB) induction by CRISPR nucleases represents a major concern. Therefore, in recent years considerable effort has been dedicated to developing methods for assessing the OT activity of CRISPR nucleases, which in turn can be used to guide engineering of nucleases with minimal OT activity.
View Article and Find Full Text PDFCorrection for Ballarino et al., "Novel Long Noncoding RNAs (lncRNAs) in Myogenesis: a Overlapping lncRNA Transcript Controls Myoblast Differentiation".
Mol Cell Biol
June 2018
Dept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
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