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Background: Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious subglottic mucosal scar. Disease rarity and wide geographic patient distribution has previously limited substantive mechanistic investigation into iSGS pathogenesis.
View Article and Find Full Text PDF[A case of progressive jaundice after transjugular intrahepatic portosystemic shunt].
Zhonghua Gan Zang Bing Za Zhi
February 2023
Department of Gastroenterology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Splenomegaly in a Patient with a History of Pernicious Anemia; the Potential Therapeutic Effects of B12 Therapy.
Case Rep Hematol
April 2022
St. Joseph's University Medical Center, 703 Main St., Paterson, NJ 07503, USA.
Splenomegaly is manifested by a variety of etiologies, one of which is macrocytic anemia. Macrocytic anemia has multiple causes in itself that include; folate (Vitamin B9) and Cobalamin (vitamin B12) deficiencies. In this case report, we present a patient with a history of pancytopenia, macrocytic anemia and vitamin B12 deficiency, who underwent a splenectomy.
View Article and Find Full Text PDFComorbid diseases of vitiligo: A 10-year cross-sectional retrospective study of an urban US population.
J Am Acad Dermatol
March 2020
Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, California. Electronic address:
Background: Vitiligo is associated with medical conditions, primarily autoimmune disorders; however, only a few studies in the United States have investigated these associations.
Objective: Our purpose was to investigate the diseases associated with vitiligo in the New York, New York, population and evaluate if these associations differ by race/ethnicity and sex.
Methods: In this retrospective study, we analyzed data collected from the medical records of 1487 vitiligo patients seen at New York University during a 10-year period.
Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis.
Am J Physiol Lung Cell Mol Physiol
August 2019
Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois.
Idiopathic pulmonary fibrosis (IPF) is a pernicious lung disease characterized by alveolar epithelial apoptosis, dysregulated repair of epithelial injury, scar formation, and respiratory failure. In this study, we identified phospholipase D (PLD)-generated phosphatidic acid (PA) signaling in the development of pulmonary fibrosis (PF). Of the PLD isoenzymes, the protein expression of PLD2, but not PLD1, was upregulated in lung tissues from IPF patients and bleomycin challenged mice.
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