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Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility.
Nat Commun
January 2025
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
It remains unclear whether the benefits of adhering to a healthy lifestyle outweigh the effects of high genetic risk on cognitive decline. We examined the association of combined lifestyle factors and genetic risk with changes in cognitive function and six specific dimensions of cognition among older adults from the Chinese Longitudinal Healthy Longevity Survey (1998-2018, n = 18,811, a subset of 6301 participants with genetic information). Compared to participants with an unfavorable lifestyle, those with a favorable lifestyle showed a 46.
View Article and Find Full Text PDFRepeated social stress increases posterior medial amygdala neuronal activity in stress-susceptible adult male rats.
J Neurophysiol
January 2025
Department of Foundational Sciences and Humanities, Discipline of Cellular & Molecular Pharmacology, Rosalind Franklin University, North Chicago, IL, USA, 60064.
The medial amygdala (MeA) is activated by social stimuli and manipulations of the MeA disrupt a wide range of social behaviors. Social stress can shift social behaviors and may accomplish this partly via effects on the MeA. However, very little is known about the effects of social stress on the electrophysiological activity of MeA neurons.
View Article and Find Full Text PDFTelomere Length Differences Indicate Climate Change-Induced Stress and Population Decline in a Migratory Bird.
Mol Ecol
January 2025
Department of Biology, Colorado State University, Fort Collins, Colorado, USA.
Genomic projections of (mal)adaptation under future climate change, known as genomic offset, faces limited application due to challenges in validating model predictions. Individuals inhabiting regions with high genomic offset are expected to experience increased levels of physiological stress as a result of climate change, but documenting such stress can be challenging in systems where experimental manipulations are not possible. One increasingly common method for documenting physiological costs associated with stress in individuals is to measure the relative length of telomeres-the repetitive regions on the caps of chromosomes that are known to shorten at faster rates in more adverse conditions.
View Article and Find Full Text PDFChildhood High Adiposity has no Advantage for Height in Adulthood: Cross-Sectional Studies in Indonesian Children to Young Adults.
Int J Prev Med
November 2024
Department of Child Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Childhood obesity is associated with faster linear growth; nonetheless, its benefit to the mature height of Indonesian children is questionable. This study aimed to evaluate the relationship between adiposity and height growth of Indonesian children, adolescents, and young adults aged 7 to 23 years.
Methods: Height and skinfolds at triceps, subscapular, suprailiac, and calf were measured in 2,520 children, adolescents, and young adults aged 7 to 23 years (boys = 1,116, girls = 1,404).
Smoking-attributable peptic ulcer disease mortality worldwide: trends from 1990 to 2021 and projections to 2046 based on the global burden of disease study.
Front Public Health
January 2025
Department of Rheumatology and Immunology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Objective: Smoking is a major risk factor for peptic ulcer disease (PUD) mortality. This study aims to analyze global trends in smoking-attributable PUD mortality from 1990 to 2021 and project future trends to 2046.
Methods: Data were obtained from the Global Burden of Disease Study 2021.
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