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Serum Concentrations of Pro- and Anti-Inflammatory Cytokines in Wistar Rats Subjected to Immobilization Stress and Treated with Tuftsin-Pro-Gly-Pro Peptide.
Bull Exp Biol Med
November 2024
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
It was found that 28-day immobilization stress in male Wistar rats leads to significant increase in the serum concentrations of proinflammatory cytokines IL-1β, IL-6, IFNγ, and monocyte chemoattractant protein-1 (MCP-1) and a decrease in the content of anti-inflammatory IL-10, as well as the ratio IL-1β/IL-10, IL-6/IL-10, and IFNγ/IL-10 compared to non-stressed animals. Administration of the heptapeptide tuftsin-Pro-Gly-Pro produced a corrective effect on cytokine concentrations under stress conditions: at a dose of 750 μg/kg, the peptide decreased the concentrations of IL-1β, IFNγ, and MCP-1 and cytokine ratios (IL-1β/IL-10 and IFNγ/IL-10), while at a dose of 250 μg/kg, it increased IL-10 levels and decreased IL-6/IL-10 and IFNγ/IL-10 ratios.
View Article and Find Full Text PDFHelminth derivative tuftsin-phopshorylcholine to treat autoimmunity.
Autoimmun Rev
October 2024
Zabludowicz center for autoimmune diseases, Sheba Medical Center, Ramat Gan. Israel; Reichman University, Herzelia, Israel.
Autoimmune diseases (AIDs) affect 5 to 10% of the population. There are more than ∼100 different autoimmune diseases. The AIDs are one of the top 10 causes of death in women under 65; 2nd highest cause of chronic illness; top cause of morbidity in women in the US.
View Article and Find Full Text PDFMonitoring ROS Responsive FeO-based Nanoparticle Mediated Ferroptosis and Immunotherapy via Xe MRI.
Angew Chem Int Ed Engl
May 2024
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, P. R. China.
Article Synopsis
- The immune checkpoint blockade has boosted survival rates for late-stage lung cancer, but its effectiveness is limited by a low immune response.
- A new ROS-responsive FeO-based nanoparticle enhances immune response by disassembling in the tumor microenvironment, promoting tumor cell uptake and causing severe ferroptosis.
- This innovative approach, combined with immune activation and evaluation methods, shows promise for improving lung metastasis treatment and overall cancer therapy.
Tuftsin-tailored fusion protein inhibits the growth of circulating gastric tumor cells associated with macrophage phagocytosis.
Biochem Biophys Rep
July 2023
Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong Province, 250117, China.
Circulating tumor cells (CTCs) are a major cause of tumor metastasis and resistance to anticancer therapies. To date, no effective low-toxicity chemotherapeutic agents or antibodies have exhibited significant clinical activity against CTCs. Macrophages are important mediators of antitumor immunity.
View Article and Find Full Text PDFSelank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Bull Exp Biol Med
October 2022
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model. Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.
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