Objective: To measure spermatogenesis abnormalities in transwomen at the time of sex reassignment surgery (SRS) and to analyze the association between hormonal therapy duration and infertility severity.
Design: Retrospective study.
Setting: University hospital.
Patients: One-hundred seventy-three transwomen who underwent SRS from January 2000 to December 2015.
Interventions: All orchidectomy specimens were retrospectively reviewed and classified. History of hormonal therapy duration was retrieved from medical records.
Main Outcome Measures: Histological examinations of orchidectomy specimens were performed to assess spermatogenesis.
Results: One-hundred seventy-three orchidectomy specimens were evaluated. Histological examinations showed maturation arrest in 36.4%, hypospermatogenesis in 26%, Sertoli cell-only syndrome in 20.2%, normal spermatogenesis in 11%, and seminiferous tubule hyalinization in 6.4% of the specimens. Spermatogenesis abnormality severity was not associated with the total therapy duration ( = 0.81) or patient age at the time of surgery ( = 0.88). Testicular volumes and sizes were associated with spermatogenesis abnormality severity ( = 0.001 and = 0.026, right testicle and left testicle, resp.).
Conclusions: Feminizing hormonal treatment leads to reductions in testicular germ cell levels. All transwomen should be warned about this consequence, and gamete preservation should be offered before starting hormonal treatment.
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| http://dx.doi.org/10.1155/2018/7919481 | DOI Listing |
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