Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.

Trends Genet

Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt. Electronic address:

Published: August 2018

Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055012PMC
http://dx.doi.org/10.1016/j.tig.2018.04.006DOI Listing

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