AI Article Synopsis
- A new type of nanoparticles made from chitosan-stabilized PLGA was created to specifically attack colon adenocarcinoma cells.
- These nanoparticles are designed to release the chemotherapy drug SN38 in a controlled manner, ensuring that more of the drug reaches the cancer cells.
- In both lab tests and live studies, these targeted nanoparticles demonstrated better effectiveness and less toxicity compared to non-targeted treatments.
Article Abstract
New integrin-targeted nanoparticles made of chitosan-stabilized PLGA matrix was developed to specifically target colon adenocarcinoma. To this aim, SN38-encapsulated chitosan-coated PLGA NPs were conjugated with tetrac for integrin receptor-guided delivery. To provide a sustained release pattern for SN38, it was loaded into nanoparticles using single emulsion method. The size of NPs were 174.23 ± 6.12 nm with drug encapsulation efficiency and loading content of 73.16 ± 11.15 and 4.45 ± 0.31, respectively. The in vitro results confirmed that the designed nanoplatform showed specific cellular uptake and cytotoxicity in integrin overexpressing cancer cells and provided a sustained release profile for SN38. Additionally, an increased therapeutic potency of targeted formulation over both non-targeted and free drug was shown in vivo.
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| http://dx.doi.org/10.1080/21691401.2018.1477789 | DOI Listing |
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