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Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells. | LitMetric
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This scenario highlights the need for novel compounds with high potential for TNBC treatment. In this regard, natural products are important sources of anticancer drugs. D-Fraction, a proteoglucan extracted from the edible and medicinal mushroom (Maitake), is a dietary supplement that has been shown to exert both immunostimulatory and immune-independent antitumoral effects on some cancer types. However, its antitumoral potential in TNBC is unknown. Therefore, we employed TNBC cells to investigate if D-Fraction is able to attenuate their aggressive phenotype. We found that D-Fraction decreases MDA-MB-231 cell through induction and reduces their metastatic potential. D-Fraction increases by increasing E-cadherin protein levels and β-catenin membrane localization, and increases . D-Fraction also decreases cell by affecting actin cytoskeleton rearrangements, and of MMP-2 and MMP-9. Furthermore, D-Fraction decreases the capacity of MDA-MB-231 cells. In concordance, D-Fraction and in a xenograft model. Altogether, these results suggest the potential therapeutic role of D-Fraction in aggressive TNBC.
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