Intravascular laser coagulation of experimental aneurysms.

Acta Radiol Suppl

Department of Radiology, Beth Israel Hospital, Boston, Massachusetts.

Published: May 1992

Rebleeding after aneurysmal subarachnoid hemorrhage has a 45 per cent mortality rate. The peak incidence is within 24 hours of the initial bleed. During the ensuing 2 weeks 20 per cent of patients with suffer a second hemorrhage. To avoid this, surgical treatment must be instituted promptly but, logistically, this is often difficult to implement. To this end, we have devised an intravascular laser-catheter technique that may provide expeditious treatment for intracranial aneurysms. We have coagulated experimental aneurysms in the rabbit carotid artery using laser energy transmitted through an intra-arterial optical fiber. The special fiber tip was positioned in the aneurysm by a catheter introduced from the femoral artery. Laser power of 750 mW and an exposure of 15 seconds caused aneurysm ablation leaving the feeding artery patent. To date, 4 experimental aneurysms have been occluded by this technique and long term histologic results are pending in this ongoing study.

Download full-text PDF

Source

Publication Analysis

Top Keywords

experimental aneurysms
12
artery laser
8
intravascular laser
4
laser coagulation
4
coagulation experimental
4
aneurysms
4
aneurysms rebleeding
4
rebleeding aneurysmal
4
aneurysmal subarachnoid
4
subarachnoid hemorrhage
4

Similar Publications

Thrombolysis for aneurysmal subarachnoid haemorrhage.

Cochrane Database Syst Rev

January 2025

Ageing Clinical and Experimental Research, University of Aberdeen, Aberdeen, UK.

Background: Aneurysmal subarachnoid haemorrhage continues to cause a significant burden of morbidity and mortality despite advances in care. Trials investigating local administration of thrombolytics have reported promising results.

Objectives: - To assess the effect of thrombolysis on improving functional outcome and case fatality following aneurysmal subarachnoid haemorrhage - To determine the effect of thrombolysis on the risk of cerebral artery vasospasm, delayed cerebral ischaemia, and hydrocephalus following subarachnoid haemorrhage - To determine the risk of complications of local thrombolysis in aneurysmal subarachnoid haemorrhage SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (last searched 9 March 2023), MEDLINE Ovid (1946 to 9 March 2023), and Embase Ovid (1974 to 9 March 2023).

View Article and Find Full Text PDF

Background: Aneurysmal bone cysts (ABCs) are benign, blood-filled neoplasms causing bone destruction, often requiring resection. However, challenges arise, especially at the cranio-cervical junction, where proximity to critical structures limits removal. Non-surgical options include selective arterial embolization (SAE) as main treatment, while Denosumab and centrifugated bone marrow emerge as experimental alternatives.

View Article and Find Full Text PDF

Treatment with an inhibitor of glucose use via glucose transporters (GLUT) has been shown to attenuate experimental abdominal aortic aneurysm (AAA) development in mice. Vascular smooth muscle cell (VSMC) signaling seems to be essential for angiotensin II (Ang II)-induced AAA in mice. Accordingly, we have tested a hypothesis that VSMC silencing of the major GLUT, GLUT1, prevents AAA development and rupture in mice treated with Ang II plus β-aminopropionitrile.

View Article and Find Full Text PDF

Abdominal aortic aneurysm (AAA) is a severe cardiovascular disease (CVD) that is partly attributable to endothelial dysfunction, inflammatory response, and angiogenesis. G protein-coupled receptor 4 (GPR4), a proton-sensitive G protein-coupled receptor that is abundantly expressed in vascular endothelial cells, has been associated with numerous physiological functions. Nevertheless, its potential involvement in the development of AAA remains unexplored.

View Article and Find Full Text PDF

Aneurysm modeling and simulation play an important role in many specialist areas in the field of medicine such as surgical education and training, clinical diagnosis and prediction, and treatment planning. Despite the considerable effort invested in developing computational fluid dynamics so far, visual simulation of blood flow dynamics in aneurysms, especially the under-explored aspect of bifurcation aneurysms, remains a challenging issue. To alleviate the situation, this study introduces a novel Smoothed Particle Hydrodynamics (SPH)-based method to model and visually simulate blood flow, bifurcation progression, and fluid-structure interaction.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!