The aim of the current study is to investigate corneal biomechanical properties in detail using Ocular Response Analyzer (ORA) and Corvis ST (CST) tonometry and to analyze the association between corneal biomechanical properties and the frequency of intravitreal anti-vascular endothelial growth factor (VEGF) injections (F) in AS eyes with choroidal neovascularization (CNV). Twenty-eight eyes of 15 patients with AS were enrolled. Mean age of AS patients was 67.9 ± 9.8 years. ORA and CST measurements were carried out, in addition to comprehensive ophthalmic examinations. LogMAR visual acuity (VA) and ΔVA (the change of VA from baseline to the final visit) were calculated in each eye. Also, the relationships between F, and the variables of initial age at the observation period, axial length, and corneal biomechanical properties were investigated in eyes with AS using linear mixed model with model selection using AICc. In 28 AS eyes, 16 eyes underwent intravitreal anti-VEGF injections during follow-up period. Lower corneal hysteresis (CH), higher corneal resistant factor (CRF) and higher CST measured the DA ratio were associated with the increase of F in AS eyes (p = 0.01, p = 0.002, p = 0.027, respectively), suggesting the usefulness for monitoring of corneal biomechanical properties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970224 | PMC |
| http://dx.doi.org/10.1038/s41598-018-26430-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Corneal Confocal and Specular Microscopic Characteristics in Primary Open-Angle Glaucoma: An Optical Coherence Tomography (OCT)-Based Case-Control Study.
Cureus
December 2024
Cornea and Refractive Surgery, Al-Shifa Trust Eye Hospital, Rawalpindi, PAK.
Background: Glaucoma, particularly open-angle glaucoma (OAG), is a leading cause of irreversible blindness, associated with optic nerve damage, retinal ganglion cell death, and visual field defects. Corneal biomechanical properties and cellular components, such as corneal nerve and keratocyte densities assessed by in vivo confocal microscopy (IVCM), may serve as biomarkers for glaucoma progression. This study aimed to explore the relationship between corneal nerve parameters, keratocyte density, and optical coherence tomography (OCT)-derived retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) patients and controls.
View Article and Find Full Text PDFEstablishment and evaluation of rabbit model for corneal ectasia by photorefractive keratectomy.
Exp Eye Res
January 2025
Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
The study aimed to compare the effects of different types of excimer laser keratectomy on rabbit corneas and to identify the optimal disease model for corneal ectasia. Additionally, investigating the structural and molecular alterations in the novel disease model helped explore the mechanisms underlying biomechanical cues in corneal ectasia. 2.
View Article and Find Full Text PDFStrategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.
J Clin Med
January 2025
Department of Optometry and Vision Science, Hadassah Academic College, Jerusalem 9101001, Israel.
Keratoconus is a progressive corneal disorder that can lead to irreversible visual impairment if not detected early. Despite its high prevalence, early diagnosis is often delayed, especially in low-to-middle-income countries due to limited awareness and restricted access to advanced diagnostic tools such as corneal topography, tomography, optical coherence tomography, and corneal biomechanical assessments. These technologies are essential for identifying early-stage keratoconus, yet their high cost limits accessibility in resource-limited settings.
View Article and Find Full Text PDFThe corneal biomechanical changes of phacoemulsification in cataract patients: A systematic review and meta-analysis.
PLoS One
January 2025
School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, P. R. China.
Purpose: To evaluate the corneal biomechanical properties of phacoemulsification in the treatment of cataract patients.
Methods: Pertinent studies were searched in PubMed, EMBASE, Web of Science and clinicaltrials.gov.
Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus.
Invest Ophthalmol Vis Sci
January 2025
Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, Maryland, United States.
Purpose: Although mechanical injury to the cornea (e.g. chronic eye rubbing) is a known risk factor for keratoconus progression, how it contributes to loss of corneal integrity is not known.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!