Functionalized folic-polymers were often used for gene and drug delivery. DNA binding to folic acid-PAMAM conjugates was studied, using multiple spectroscopic methods, thermodynamic analysis and transmission electron microscopy (TEM). Thermodynamic parameters showed DNA-folic acid-PAMAM conjugation occurs via H-bonding, hydrophobic and van der Waals contacts. As nanoparticle size increases the loading efficacy and the stability of DNA conjugates are enhanced. TEM analysis showed major DNA morphological changes, upon folic acid-PAMAM conjugation. Folic acid-PAMAM nanoparticles can transport DNA in vitro.
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