Active tiebacks using elastomeric modules are preferred for space closure in most cases. Elastomeric ring should be stretched by equal amount on both sides for equalforce delivery and to avoid unwanted complication like shift in mid-line, asymmetric space closure. Elastic tiebacks were originally described using an elastomeric module, stretched to twice its normal size but in clinical situations, stretch of elastomeric rings are diffcult to measure intraorally. This paper introduces a manually fabricated guiding system that will allow the clinician to accurately activate active tie-back bilaterally without fear of over/under stretching the module to twice its original size. With the help of straight length 0.021" 0.025" SS wire and cold cure acrylic a guiding stent is fabricated. Guiding loops were made with 0.009" ligature wire around this stent, which can be placed along with active tieback. This "Exactive tieback" with the help ofguiding loop template is easy to fabricate and use. It is an accurate, effective, and predictable method for placement of symmetrical active tie-backs."
Download full-text PDF |
Source |
---|
Cureus
September 2024
Orthodontics and Dentofacial Orthopedics, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, IND.
Introduction: Canine retraction is critical in orthodontic treatment, requiring precise force application. Elastomeric chains and active tiebacks are commonly used materials, but their efficacy in maintaining the force over time needs further evaluation. The study aimed to compare the rate of force degradation of elastomeric chains vs.
View Article and Find Full Text PDFACS Chem Neurosci
September 2024
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Herein, we report structure-activity relationship (SAR) studies to develop novel tricyclic M PAM scaffolds with improved pharmacological properties. This endeavor involved a "tie-back" strategy to replace a 5-amino-2,4-dimethylthieno[2,3-]pyrimidine-6-carboxamide core, which led to the discovery of two novel tricyclic cores. While both tricyclic cores displayed low nanomolar potency against both human and rat M and were highly brain-penetrant, the 2,4-dimethylpyrido[4',3':4,5]thieno[2,3-]pyrimidine tricycle core provided lead compound, , with an overall superior pharmacological and drug metabolism and pharmacokinetics (DMPK) profile, as well as efficacy in a preclinical antipsychotic animal model.
View Article and Find Full Text PDFObjectives: Evaluation of the strength of the novel suture technique by comparison with a 2-interrupted suture technique.
Sample: 40 equine larynges.
Procedures: 40 larynges were used; 16 laryngoplasties were performed using the currently accepted 2-suture technique and 16 using the novel suture technique.
Bioorg Med Chem Lett
December 2021
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:
This Letter details our efforts to develop novel tricyclic M PAM scaffolds with improved pharmacological properties. This endeavor involved a "tie-back" strategy to replace the 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide core which lead to the discovery of two novel tricyclic cores: a 7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidine core and 2,4-dimethylthieno[2,3-b:5,4-c']dipyridine core. Both tricyclic cores displayed low nanomolar potency against the human M receptor.
View Article and Find Full Text PDFJ Contemp Dent Pract
August 2017
Department of Community Dentistry, Maulana Azad Dental College & Hospital, New Delhi, India, Phone: +919501544877, e-mail:
Aim: Orthodontic treatment is routinely carried out in patients with the purpose of correcting various forms of dental malocclusions. Retraction of the canines can be achieved either individually or along with incisor. Pentraxin-3 (PTX-3) is regarded as the true independent indicator of disease activity.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!