Synthesizing results from multiple studies is a daunting task during which researchers must tackle a variety of challenges. The task is even more demanding when studying developmental processes longitudinally and when different instruments are used to measure constructs. Data integration methodology is an emerging field that enables researchers to pool data drawn from multiple existing studies. To date, these methods are not commonly utilized in the social and behavioral sciences, even though they can be very useful for studying various complex developmental processes. This article illustrates the use of two data integration methods, the and the approaches. The illustration makes use of six longitudinal studies of mathematics ability in children with a goal of examining individual changes in mathematics ability and determining differences in the trajectories based on sex and socioeconomic status. The studies vary in their assessment of mathematics ability and in the timing and number of measurement occasions. The advantages of using a data fusion approach, which can allow for the fitting of more complex growth models that might not otherwise have been possible to fit in a single data set, are emphasized. The article concludes with a discussion of the limitations and benefits of these approaches for research synthesis.
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http://dx.doi.org/10.1177/0013164416664117 | DOI Listing |
Hum Genomics
January 2025
Division of Genome Science, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Chungbuk, 28159, Republic of Korea.
Background: Congenital anomalies (CAs) encompass a wide spectrum of structural and functional abnormalities during fetal development, commonly presenting at birth. Identifying the cause of CA is essential for accurate diagnosis and treatment. Using a target-gene approach, genetic variants could be found in certain CA patients.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130000, China.
Background: Recent studies suggest a connection between immunoglobulin light chains (IgLCs) and coronary heart disease (CHD). However, current diagnostic methods using peripheral blood IgLCs levels or subtype ratios show limited accuracy for CHD, lacking comprehensive assessment and posing challenges in early detection and precise disease severity evaluation. We aim to develop and validate a Coronary Health Index (CHI) incorporating total IgLCs levels and their distribution.
View Article and Find Full Text PDFChiropr Man Therap
January 2025
Department of Chiropractic Medicine, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Background: Spinal manipulation (MAN) and mobilization (MOB) are biomechanically different yet both elicit pain reduction and increased range of motion. Previous investigations have focused on quantifying kinetics (e.g.
View Article and Find Full Text PDFInfect Chemother
December 2024
Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.
Background: The life expectancy of people living with human immunodeficiency virus (PLWH) has significantly improved with advancements in antiretroviral therapy (ART). However, aging PLWH face a growing burden of non-communicable diseases (NCDs), polypharmacy, and drug-drug interactions (DDIs), which pose challenges in their management. This study investigates the prevalence of NCDs, polypharmacy, and DDIs among PLWH aged ≥50 years in Korea and their impact on quality of life (QOL).
View Article and Find Full Text PDFJ Transl Med
January 2025
State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, 200120, China.
Background: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches.
Methods: We constructed a single-cell transcriptional atlas of DCM and normal patients.
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