[This corrects the article DOI: 10.1371/journal.pone.0158878.].

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967801PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198020PLOS

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Article Synopsis
  • The study investigates how the symptoms of social signal processing in Prader-Willi Syndrome (PWS) can be influenced by neuropeptides oxytocin (OXT) and vasopressin (AVP), particularly focusing on their effects in the lateral septum (LS) of the brain.
  • It uses a mouse model with a knockout of the Magel2 gene, employing various experimental techniques to observe the role of OXT and AVP in social-fear situations and identify neuronal pathways involved.
  • The findings reveal that deficits in OXT and AVP signaling lead to disrupted social-fear responses by affecting certain inhibitory neurons in the LS, providing insights that could pave the way for new treatment strategies for autism spectrum disorders.
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Aim: To compare trajectories of social functioning in peer problems and prosocial behavior from 5 to 13 years between individuals born very preterm (VPT) and full-term (FT).

Methods: Participants were from the Victorian Infant Brain Study (VIBeS) longitudinal cohort, consisting of 224 individuals born VPT and 77 born FT recruited at birth. Social functioning was measured using the parent-rated Strengths and Difficulties Questionnaire (SDQ) peer problems and prosocial behavior subscales at 5, 7, and 13 years' corrected age.

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R-Baclofen Treatment Corrects Autistic-like Behavioral Deficits in the RjIbm(m):FH Fawn-Hooded Rat Strain.

Pharmaceuticals (Basel)

July 2024

Pharmacology and Drug Safety Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103 Budapest, Hungary.

The Fawn-hooded rat has long been used as a model for various peripheral and central disorders and the data available indicate that the social behavior of this strain may be compromised. However, a thorough description of the Fawn-hooded rat is unavailable in this regard. The objective of the present study was to investigate various aspects of the Fawn-hooded rat's social behavior in depth.

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