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Characterizing the Effects of Concussion and Head Impact Exposure: Design, Methods, and Participant Traits of the CARE 2.0 Study.

J Neuropsychiatry Clin Neurosci

October 2024

Department of Psychiatry (McAllister) and Department of Biostatistics and Health Data Science (Perkins, Katz), Indiana University School of Medicine, Indianapolis; Michigan Concussion Center, University of Michigan, Ann Arbor (Broglio); Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis (Perkins, Katz); Department of Physical Medicine and Rehabilitation, Uniformed Services University, and Department of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, Md. (Pasquina); Department of Neurosurgery, Medical College of Wisconsin, Milwaukee (McCrea).

Article Synopsis
  • The article outlines the second phase of the CARE Consortium study, which investigates the neuropsychiatric effects of concussions and repeated head impacts on collegiate athletes and military cadets.
  • Participants were evaluated at three stages: undergraduate baseline, exit from school or academy, and up to 6 years post-graduation, using online brain health assessments.
  • While there were some statistical differences in participant characteristics over time, the overall findings indicate that exit and postgrad groups largely resemble the baseline group, allowing for valuable insights into the long-term impacts of head injuries.
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Background: A critical first step in managing functional neurological disorder (FND) is a positive diagnosis and clear explanation using an understandable illness model. Multidisciplinary group education sessions are one way to achieve this, with some evidence they improve understanding, confidence in diagnosis and outcomes with further treatment. In many conditions, illness perceptions and stigma affect distress, functioning, quality of life and engagement.

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Therapeutic potential of gamma entrainment using sensory stimulation for cognitive symptoms associated with schizophrenia.

Neurosci Biobehav Rev

June 2024

Department of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that address the spectrum of symptoms are limited, highlighting the need for innovative therapeutic approaches. Gamma Entrainment Using Sensory Stimulation (GENUS) is an emerging treatment for neuropsychiatric disorders that uses sensory stimulation to entrain impaired oscillatory network activity and restore brain function.

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Introduction: The competence assessment to give informed consent in the legal and healthcare settings is often performed merely through clinical judgment. Given the acknowledged limited reliability of clinician-based evaluation in the mental health sector, particularly for the assessment of competence to consent, our objective was to ascertain the dependability of clinical judgment when evaluating the ability of schizophrenia patients to make choices about their health.

Methods: The potential convergence between clinical evaluation and scores from a new standardized assessment (the "Evaluation of Informed Consent to Treatment" - "EICT" scale) was therefore tested.

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Schizophrenia, a complex neuropsychiatric condition, manifests with severe neurobiological and psychosocial symptoms, including psychosis, cognitive dysfunction, and social withdrawal. Neuroscience links these symptoms to synaptic malfunctions and neurotransmitter dysregulation, leading to a profound disconnection from reality. The disorder significantly affects cognitive, affective, and behavioral functions, causing considerable neuropsychological distress and functional impairments.

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