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Outcomes of paediatric community acquired pneumonia.
Paediatr Respir Rev
October 2024
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK. Electronic address:
Article Synopsis
- Community-acquired pneumonia is a leading reason for child hospitalizations, but most cases are treated effectively on an outpatient basis.
- Empyema is the main complication for hospitalized pneumonia patients, leading to significant health issues but rarely resulting in death, even in severe cases.
- Long-term studies show childhood pneumonia can impair lung function and increase the risk of chronic respiratory diseases in adulthood, yet most children have only minor lung function issues during follow-up assessments.
Asthma and health-related quality of life at 16-20 years of age in a prospectively followed post-bronchiolitis cohort.
Eur J Pediatr
November 2024
Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön Katu 34, 33520, Tampere, Finland.
Unlabelled: The aim was to evaluate asthma and health-related quality of life (HRQoL) outcomes in adolescents, after hospital-treated bronchiolitis experienced in less than 6 months of age. A prospective cohort study started in 2001-2004 and followed up 166 children hospitalised for bronchiolitis in early infancy. At 16-20 years of age, 76 cases and 41 population-based controls without a history of bronchiolitis participated in the current study.
View Article and Find Full Text PDFLooking beyond LCI: Multiple breath washout phase III slope derived indices and their application in chronic respiratory disease in children.
Pediatr Pulmonol
December 2024
Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health (UCL GOS ICH), London, UK.
The multiple breath washout (MBW) test is widely reported in the context of Lung Clearance Index (LCI). LCI reflects global ventilation inhomogeneity but does not provide information regarding the localization of disease along the respiratory tree. The MBW-derived normalized phase III slope (S) indices (S and S), instead, can distinguish between convective-dependent and diffusion-convection-dependent ventilation inhomogeneity considered to occur within the conductive and acinar airways, respectively.
View Article and Find Full Text PDFLate-Onset Noninfectious Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center Experience.
Exp Clin Transplant
May 2024
>From the Department of Chest Diseases, Ankara University Faculty of Medicine, Ankara, Turkey.
Objectives: We aimed to reveal the incidence of lateonset noninfectious pulmonary complications and bronchiolitis obliterans syndrome and risk factors involved in development.
Materials And Methods: In this cross-sectional study, we retrospectively investigated 745 patients who underwent allogeneic hematopoietic stem cell transplantation in our hospital between January 2000 and December 2020. We evaluated demographic characteristics, comorbidities, and hematopoietic stem cell transplantation characteristics to determine possible risk factors affecting development of lateonset noninfectious pulmonary complications and bronchiolitis obliterans syndrome.
Diagnosis of Post-Hematopoietic Stem Cell Transplantation Bronchiolitis Obliterans Syndrome in Children: Time for a Rethink?
Transplant Cell Ther
August 2024
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota; Division of Pulmonary Medicine, Masonic Children's Hospital, Minneapolis, Minnesota.
Hematopoietic stem cell transplantation (HSCT) is undertaken in children with the aim of curing a range of malignant and nonmalignant conditions. Unfortunately, pulmonary complications, especially bronchiolitis obliterans syndrome (BOS), are significant sources of morbidity and mortality post-HSCT. Currently, criteria developed by a National Institutes of Health (NIH) working group are used to diagnose BOS in children post-HSCT.
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