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| http://dx.doi.org/10.1016/j.healun.2018.01.1310 | DOI Listing |
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Case Report: Human Tracheal Transplantation Undergoes Progressive Reepithelialization Over Time.
Laryngoscope
June 2024
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.
Objectives: Tracheal transplantation is an ideal option for the reconstruction of long-segment circumferential tracheal defects. Our group performed the first successful vascularized single-staged tracheal transplantation in January 2021. Although a rigid biocompatible structure is necessary for a functioning tracheal replacement, the importance of ciliated epithelium, which allows for critical mucociliary clearance, is now being appreciated.
View Article and Find Full Text PDFNK-cell post-transplant lymphoproliferative disease successfully treated by second allogenic hematopoietic stem cell transplantation in chronic active Epstein-Barr virus infection.
Int J Hematol
April 2022
Department of Hematology, Kitano hospital, Medical Research Institute, 2-4-20, Ougimachi, Kita-ku, Osaka, Japan.
Chronic active Epstein-Barr virus infection (CAEBV) is a systemic T- or NK-lymphoproliferative disorder (LPD) caused by EBV. Allogenic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for CAEBV, but relapse sometimes occurs. Relapse is generally attributed to proliferation of recipient-derived CAEBV cells.
View Article and Find Full Text PDFDonor HLA genotyping of ex vivo expanded urine cells from kidney transplant recipients.
HLA
November 2021
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Antibody-mediated rejection (AMR) induced by donor-specific anti-HLA antibodies (DSA) remains a major cause of long-term graft loss after kidney transplantation. Currently, the presence of DSA cannot always be determined at a specific allele level, because existing donor HLA typing is low resolution and often incomplete, lacking HLA-DP, and occasionally HLA-C and HLA-DQ information and historical donor DNA samples are not available for HLA retyping. Here we present a novel, non-invasive technique for obtaining donor DNA from selectively expanded donor cells from urine of renal transplant recipients.
View Article and Find Full Text PDFRapidly progressive metastatic adenocarcinoma of unknown primary 2 months following deceased donor renal transplantation-Donor- or recipient-derived?
Nephrology (Carlton)
February 2021
Adelaide Medical School, University of Adelaide, Adelaide, South Australia.
Interrogating the impact of KIR ligand mismatch in engraftment following HLA-disparate stem cell transplantation.
Bone Marrow Transplant
December 2020
Stem Cell Transplant Program, University Hospitals Seidman Cancer Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
The effects of donor-derived natural killer (NK) cell alloreactivity on disease relapse and transplant-related mortality following allogeneic stem cell transplantation have been described while the impact of recipient-derived NK cell alloreactivity on donor engraftment is not well known. Epitopes of HLA Class I molecules act as ligands for NK cell killer immunoglobulin-like receptors (KIR) regulating their cytotoxicity. As such, NK cell alloreactivity is predictable from KIR ligand mismatches between donors and recipients.
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